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While marijuana is believed to have some effect on genes, scientists have only recently begun to investigate how it might apply to medicine.

In the latest study, published in the Journal of Biological Chemistry, researchers at the USC School of Medicine identified a specific set of microRNA (miRNA) molecules that were altered in rats dosed with THC.

miRNA play a role in regulating genes and are believed to contribute to a number of diseases. Out of 609 different miRNAs that the study looked at, 13 appeared to be significantly affected by THC, including one (mir-690) that is strongly linked to inflammatory responses.

The study was led by Prakash Nagarkatti, Ph.D and Mitzi Nagarkatti, Ph.D, who have spent more than a decade investigating the role of THC in autoimmune diseases, reports The State.

The researchers believe THC's effect on mir-690 expression is especially promising, concluding that further research could lead to new therapies for "inflammatory diseases as well as cancer."

Dr. Mitzi Nagarkatti elaborated on the findings in an interview with Counsel & Heal:

"While our study identifies the molecular mechanism of immune-altering effects of marijuana, select microRNA identified here could serve as important molecular targets to manipulate MDSC activity in cancer and inflammatory diseases."

Earlier this year (article from Nov. 2013 - N. Red. TurismoAssociati.it), a group from Italy obtained promising results with three other chemicals in marijuana – cannabidiol (CBD), cannabigerol (CBG) and cannabidivarin (CBV) – in reducing harmful genetic activity related to a variety of skin disorders, including cancer.

The Italian group also concluded that marijuana's gene-modifying potential may "extend well-beyond skin disorders" to diseases like multiple sclerosis and other forms of cancer.

The study received funding from the National Institutes of Health (NIH)

Source: LeafScience

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Studies have long shown that marijuana, THC specifically, can temporarily impair learning and memory abilities.

But researchers from Louisiana State University say they've discovered a pathway in the brain that may be responsible for marijuana's effect on memory and learning. According to Chu Chen, PhD, who led the study, disrupting this pathway may be as simple as popping a few over-the-counter painkillers.

"Our studies have solved the longtime mystery of how marijuana causes neuronal and memory impairments. The results suggest that the use of medical marijuana could be broadened if patients concurrently take a nonsteroidal anti-inflammatory drug such as ibuprofen."

Nonsteroidal anti-inflammatory drugs (NSAIDs), which include aspirin and ibuprofen, work by inhibiting the cyclooxygenase-2 (COX-2) enzyme.

In experiments with mice, published in the journal Cell, Dr. Chen and his team managed to link cognitive impairments caused by THC to an increase in COX-2 levels. But giving the mice an NSAID called Celebrex along with THC seemed to prevent these impairments.

More importantly, using models of Alzheimer's disease, the scientists confirmed that Celebrex didn't change the ability of THC to slow disease progression.

"Our results suggest that the unwanted side effects of cannabis could be eliminated or reduced, while retaining its beneficial effects, by administering a COX-2 inhibitor along with delta9-THC for the treatment of intractable medical conditions such as Alzheimer's disease."

The potential of THC to treat Alzheimer's has been the focus of a number of studies, since, as Dr. Chen notes, "there are no effective medications currently available for preventing and treating Alzheimer's disease or halting disease progression."

The study received funding from the National Institutes of Health (NIH)

Source: LeafScience

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Acute lung injury, also known as acute respiratory distress syndrome (ARDS), is a life-threatening condition caused by acute injuries or infections of the lung.

In the latest study, published in the open-access journal PLOS One, researchers from Brazil and Germany were able to protect mice from acute lung injury by increasing levels of one of the body's own cannabinoids, 2-AG (2-Arachidonoylglycerol).

"It was concluded that MAGL inhibition, and consequently the increase in 2-AG levels, produced anti-inflammatory effects in a murine model of LPS (lipopolysaccharide) - induced ALI (acute lung injury), a finding that was considered a consequence of the activation of the CB1 and CB2 receptors."

Like cannabinoids found in marijuana, 2-AG acts on specific pathways in the body called cannabinoid receptors (CB1 and CB2). Immune cells are known to have a high concentration of these receptors.

By activating cannabinoids receptors, scientists have also been able to control overactivity of the immune system – an underlying factor in a wide range of inflammatory diseases, including acute lung injury.

Since immune cells travel via the blood stream, treatment with cannabinoids could be administered without smoking and still have effect.

The researchers conducted the experiments using a chemical named JZL184, which slows the body's breakdown of 2-AG.

While the results need to be confirmed in humans, the team concludes that targeting cannabinoid pathways of the body could be "a useful therapeutic tool for the treatment of inflammatory lung diseases."

The study received funding from Fundaçăo de Amparo à Pesquisa do Estado de Săo Paulo (FAPESP) and Cnselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Source: LeafScience

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The study was conducted by Alfred Reid, MA and Elin Kondrad, MD of St. Anthony North Family Medicine Residency and included survey responses from over 500 members of the Colorado Academy of Family Physicians.

Published in the Journal of The American Board of Family Medicine, the results suggest that only a minority of doctors in Colorado support medical marijuana, but a large majority believe more training should be offered.

"Respondents to our survey demonstrate a strong desire for educational opportunities about medical marijuana at all levels of medical education."

Of the 520 family physicians that responded, only 19% agreed that medical marijuana should be recommended.

On the other hand, 80% agreed that medical marijuana education should be taught at medical schools. 82% also agreed that medical marijuana education should be part of family practice residency and 92% thought continuing medical education about medical marijuana should be available.

Interestingly, opinions on marijuana's schedule 1 classification were relatively split, with 37% in support of its classification and 44% in disagreement. As a schedule 1 substance, federal law classifies marijuana as having no recognized medical use and hinders research from being conducted.

But despite the caution expressed by most doctors, medical marijuana is widespread in Colorado. An estimated 163,856 patients – or 2% of the entire state population – are legally authorized to use medical marijuana.

Source: LeafScience

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Subject matter:
A European solution to a European issue: legalizing cannabis. The ECI Weed like to talk aims at making the EU adopt a common policy on the control and regulation of cannabis production, use and sale.

Main objectives:
There is currently a heterogeneous legal map as regards cannabis policies in the EU. The question of coherence and discrimination is worth asking. A common policy on the control and regulation of cannabis production, use and sale would: (a) ensure equality before the law and non-discrimination of all EU citizens; (b) protect consumers and monitor health security; (c) end cannabis trafficking. Let's leap toward the legalization of cannabis and the harmonization of national legislations accross the EU.

Information on this proposed initiative is available in the following languages:
English

European Commission registration number:
ECI(2013)000008

Date of registration:
20/11/2013

Click here to support this initiative

Web address of this proposed citizens' initiative in the European Commission's register:
http://ec.europa.eu/citizens-initiative/public/initiatives/ongoing/details/2013/000008/en

Names of registered contact persons:
FESEFELDT Bendix, BALAS Pierre

E-mail addresses of registered contact persons:
bendix.fesefeldt@sciencespo.fr, pierre.balas@sciencespo.fr

Names of the other registered organisers:
TOJA DE LA MUELA Delia, VERDAM Pieter David, VAN BERWAER Gaelle, TARDELL Miriam, LORIMER Marta

Website of this proposed citizens' initiative (if any):
http://weedliketotalk.wix.com/wltt

To support a European Citizens' Initiative, you must be an EU citizen (national of an EU member state) and be old enough to vote in European Parliament elections (18 except Austria where the voting age is 16).
For more information on the rules and conditions for the European Citizens' Initiative:
http://ec.europa.eu/citizens-initiative

Click here to support this initiative

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While cannabidiol (CBD) has shown anti-cancer effects in previous studies, recent research from Temple University's School of Pharmacy in Philadelphia and the California Pacific Medical Center points to a more comprehensive role of CBD in cancer therapy.

The study was co-authored by Dr. Sean McAllister, who was also one of the first scientists to demonstrate the ability of CBD to kill breast cancer cells and slow tumor growth. He explains that the latest findings show that CBD may not only slow cancer, but also prevent the nerve damage (neuropathy) and related pain caused by traditional chemotherapy drugs.

"It suggests that in patients CBD could treat neuropathies induced by first - line agents while also inhibiting cancer progression."

Published in the British Journal of Pharmacology, the researchers carried out a number of experiments involving cell culture and animal models.

Treatment with CBD was able to protect mice against nerve damage caused by the chemotherapy drug paclitaxel, without noticeable side-effects. What's more, combining CBD and paclitaxel seemed to produce a greater anti-cancer effect than either treatment alone.

According to the team, there is currently no treatment considered to be effective at reversing chemotherapy-induced pain. Overwhelming pain, especially during late stages of cancer, can sometimes lead patients to stop chemotherapy altogether.

As for CBD's potential to fight cancer, Dr. McAllister plans to begin the first human trial involving CBD as a treatment for aggressive breast cancer in the next 12 months (article dated 19 Nov, 2013 - N. Red. TurismoAssociati.it) .

The study was published ahead of print and no sources of funding were reported

Source: LeafScience

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Obiectul:
O solutie europeană pentru o problemă europeană: legalizarea canabisului. Organizatia ECI Weed are ca scop adoptarea unei politici comune in Uniunea Europeană, privind controlul si reglementarea productiei de canabis, utilizarea si vânzarea.

Obiectivele principale:
În prezent, există o hartă juridic eterogenă în ceea ce priveste politica canabisului în UE. Problema de coerentă si de discriminare merita cercetata. O politică comună privind controlul si reglementarea productiei de canabis, utilizarea si vânzarea lui, va ajuta la: (a) să asigure egalitatea în fata legii si a non-discriminării tuturor cetătenilor UE, (b) a proteja consumatorii si de a monitoriza precum si pentru a testa in laborator efectele asupra sănătătii; (c) punem punct traficului de canabis. Haideti să imbratisam legalizarea canabisului si armonizarea legislatiilor nationale disponibile in tarile europene. Ilegalizarea plantei a avut loc in anii 1930, avand efecte dezastruase asupra populatiei.

Faceti clic aici pentru a sustine această initiativă

Numărul de înregistrare atribuit de Comisia Europeană:
ECI(2013)000008

Data înregistrării:
20/11/2013

Adresa de internet a propunerii de initiativă cetătenească în registrul Comisiei Europene:
http://ec.europa.eu/citizens-initiative/public/initiatives/ongoing/details/2013/000008/en

Numele persoanelor de contact înregistrate:
FESEFELDT Bendix, BALAS Pierre

Adresele de e-mail ale persoanelor de contact înregistrate:
bendix.fesefeldt@sciencespo.fr, pierre.balas@sciencespo.fr

Numele celorlalti organizatori înregistrati:
TOJA DE LA MUELA Delia, VERDAM Pieter David, VAN BERWAER Gaelle, TARDELL Miriam, LORIMER Marta

Pagina de internet a initiativei cetătenesti (dacă există):
http://weedliketotalk.wix.com/wltt

Faceti clic aici pentru a sustine aceasta initiativa

Pentru a sustine o initiativă cetătenească europeană trebuie să fiti cetătean al UE (să fiti originar dintr-un stat membru al UE) si să aveti vârsta la care să puteti vota la alegerile pentru Parlamentul European (18 ani în toate tările cu exceptia Austriei, unde vârsta minimă este de 16 ani).
Mai multe informatii privind regulile si conditiile referitoare la initiativa cetătenească europeană:
http://ec.europa.eu/citizens-initiative

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La micul dejun mancam : Fie proteine si lipide: ceai de plante, un ou fiert, sunca slaba, branza dietetica, cafea. Fie carbohidrati si fibre: fructe (mere, kiwi, cirese, altele...) sau cereale integrale, paine din faina integrala de secara cu gem dietetic, marmelada sau magiun fara zahar, cafea.

La pranz mancam: supa de rosii; salata (bulgareasca) cu branza, sunca slaba sau oua fierte; omleta cu ciuperci; peste; gratar de pui cu fasole pastai. Sunt recomandate legumele cu exceptia cartofilor si a morcovilor. Legume oricat de multe, fara restrictie!!! Gustare optionala: migdale sau nuci. Pranzul este recomandat a fi pe baza de proteine si lipide.

La cina mancam: Fie carbohidrati si fibre: supa de legume; legume la abur; salate, fructe. Fie proteine si lipide: sunca slaba, iaurt dietetic, branza de vaci cu 0% grasime.


Daca am mancat carne la pranz nu mai mancam la cina.

Cum se combina alimentele?

O idee principala a dietei Montignac este bazata pe modul cum se combina alimentele. Astfel, se combina alimentele din 

grupa A – carnea (fiarta sau la gratar), ouale, pestele, branza de vaci degresata, sau alte lactate cu

grupa B – legumele. Niciodata nu se combina alimentele din grupa A cu cele din 

grupa C – cereale, cartofi, orez, paste, sau porumb. Si acestea tot cu legume se combina.

Concluzie: alimentele din grupa B (legumele cu exceptia cartofilor) se pot combina cu orice altceva. Alimentele din grupa A si grupa C nu trebuie niciodata combinate intre ele!

Zaharul este considerat de Michel Montignac un aliment periculos si ar trebui eliminat. Glucidele "rele" precum cartofii, orezul, porumbul, pastele fainoase rafinate, produsele de patiserie, produsele cu zahar, alcoolul, alimentele prajite sau care stau mai mult timp la cuptor trebuie eliminate din alimentatie!
In privinta fructelor, va putem spune ca recomandare generala, nu numai a dietei Montignac, ca ar fi bine sa fie consumate singure si pe stomacul gol (cu cel putin o jumatate de ora inainte de masa si cu cel putin doua ore dupa masa).


Acizii grasi polinesaturati (lipidele din peste) precum si acizii grasi mononesaturati (uleiul de masline) sunt recomandati pentru cat mai multe din mesele dvs. O alta regula a dietei este ca fructele si legumele sa fie consumate, pe cat posibil, in stare naturala, pentru a nu li se indeparta calitatile nutritive prin prelucrare termica.

Citeste si:

De ce nu slabim cu unele diete? Adevaratele motive pentru care nu functioneaza - http://www.turismoassociati.it/dblog/articolo.asp?id=3637

Cum se combina alimentele? Carnea, legumele si cerealele, cele trei grupe de alimente. - http://www.turismoassociati.it/dblog/articolo.asp?id=3638

Alimentele se impart in 3 categorii: acide, bazice si neutre, in functie de cum sunt digerate. Ce trebuie sa nu combini pentru a nu te ingrasa! - http://www.turismoassociati.it/dblog/articolo.asp?id=3636

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In an interview with two New York-based dermatologists, The Huffington Post uncovered an important aspect of marijuana's effect on the skin.

As it turns out, marijuana's medicinal ingredients are not only useful in treating certain skin conditions, but also offer the potential to make skin look younger. Dr. Bobby Buka and Dr. Ariel Ostad explain that chemicals in marijuana, called cannabinoids, are powerful antioxidants and anti-inflammatory agents.

Like red wine, Dr. Buka says moderate marijuana use could be good for the skin. But the key to harnessing these benefits is how you consume marijuana.

"The delivery system is really critical... Even a bong would be preferable (to smoking a joint)."

Indeed, smoking marijuana, like smoking cigarettes, has a negative impact on your skin, potentially countering the plant's anti-aging properties and leading your skin to age faster rather than slower. The reason seems to be that combusting marijuana releases a similar amount of carcinogens as cigarettes do.

While THC may offer some protection from the harmful by-products of smoke, Dr. Buka warns that the net effect of smoking a joint can still be a decrease in collagen production – leading to older - looking skin. He also warns that smoking marijuana can exacerbate skin conditions like psoriasis and rosacea.

Vaporizers, which heat marijuana to a lower temperature than joints or bongs, are probably the best way of overcoming these drawbacks. However, bongs are believed to filter at least some of the harmful by-products of smoke, and so may be a better choice for those without a vaporizer.

When it comes to medical use of marijuana, topical preparations are another way of avoiding the potential damage that smoke does to the skin.

On the other hand, Dr. Ostad believes that marijuana could offer other skin benefits that are independent of how you consume it. He explains that marijuana's ability to make you feel better can actually have a positive impact on skin health too.

"Those THC receptors actually can lead to increased production of neurotransmitters that make us feel better, like serotonin."

Dr. Buka adds that just being able to reduce stress can help with certain skin conditions. And in his experience, people who use marijuana are "by and large a mellower group of patients."

Source: HuffingtonPost

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Organismul uman este o masinarie complexa care trebuie sa functioneze armonios, pentru a fi in tonus mereu.

In ciuda eforturilor depuse in ultimii 20 de ani, nu a fost gasita deocamdata o dieta minune care sa si elimine starea de foame si sa si functioneze. Majoritatea dietelor se bazeaza pe infometare ascunsa (consumul te mancare voluminoasa cu valoare nutritionala foarte mica) sau pe disocierea substantelor necesare corpului (cu siguranta toata lumea este la curent cu regimul disociat).

Secretul pentru a slabi insa este cu totul altul. Persoanele supraponderale sau care au cateva kilograme in plus trebuie sainteleaga ca nu numai dieta joaca un rol important in mentinerea unui corp sanatos.

Astfel, somnul este imperativ. Corpul nostru, potrivit specialistilor, are nevoie sa isi duca la capat ciclurile de digestie si arderile intracelulare, procese foarte active in timpul somnului. Dormiti maxim 8 ore, minim 6, in fiecare noapte. Totodata, este necesara cel putin jumatate de ora de miscare, de efort sustinut, zilnic.

Pe langa aceste lucruri, cantitatea de alimente si momentul in care este consumata influenteaza foarte mult silueta. Spre exemplu, majoritatea celor supraponderali nu mananca la micul dejun. Eventual beau o cafea sau vreun suc acidulat care le pune capac pe stomac pe moment, insa ulterior le creeaza o stare de foame incredibila.Nu aceasta este solutia.

Micul dejun trebuie luat cel tarziu pana in ora 07.00 si trebuie sa fie cu adevarat copios. Este demonstrat stiintific ca un pic dejun copios nu face decat sa ofere corpului energia necesara in timpul unei zile. Pe de alta parte, odata ce prima masa vine tarziu in zi si este bogata in carbohidrati, corpul este supus unui stres imens si nu reuseste sa proceseze tot pana la ora de culcare.

Masa de pranz trebuie sa fie bogata in proteine, insa cat sa tina de foame. Masa de pranz nu trebuie sa fie deloc grea, ea avand rolul doar de a spori cantitatea de energie necesara organismului.

Totodata, cina trebuie sa aiba loc pana maxim in ora 18.00 si nu trebuie sa fie deloc bogata. O cina pentru un om normal poate consta din ceai cu diversi biscuiti organici si este de ajuns, spre deosedire de micul dejun care trebuie sa contina destul din toate grupele alimentare.

Evident, trebuie eliminate TOTAL din dieta painea alba, sucurile acidulate, mezelurie si dulciurile, in cantitati mari. Dulciuri se pot consuma in cantitati moderate, insa niciodata seara.

Asa ca, alimentele propuse pentru o astfel de dieta sunt ciupercile, ouale, carnea de pui, de peste painea neagra, orice fel de legume insa trebuie evitati cartofii, orezul si pastele. Consumati cu incredere alune si seminte neprajite si evitati pe cat posibil sa gatiti cu ulei. Totodata, SAREA trebuie scoasa TOTAL din alimentatie.

Este de evitat consumul de fast food, mancare congelata si semipreparate. Carnea de porc si cea de vita trebuie consumate doar ocazional. Evitati sa mancati prajit si nu in ultimul rand, beti foarte multa apa.

Cu o astfel de dieta, si cu mese regulate asa cum au fost descrise mai sus, veti reusi sa slabiti natural si metabolismul vostru isi va reveni, fara sa mai existe riscul de ingrasare dupa aceea...

Citeste si:

De ce nu slabim cu unele diete? Adevaratele motive pentru care nu functioneaza - http://www.turismoassociati.it/dblog/articolo.asp?id=3637

Cum se combina alimentele? Carnea, legumele si cerealele, cele trei grupe de alimente. - http://www.turismoassociati.it/dblog/articolo.asp?id=3638

Alimentele se impart in 3 categorii: acide, bazice si neutre, in functie de cum sunt digerate. Ce trebuie sa nu combini pentru a nu te ingrasa! - http://www.turismoassociati.it/dblog/articolo.asp?id=3636

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There's lots of anecdotal evidence of THC/cbd actually curing cancer. The beauty of cb1 and cb2 receptors.
03/04/2014 @ 13:35:53
By Craig Daniel Smith
That is a very good point... read my comments and message me or comment on your ideas about my comment. Lets do something about this.Sounds like a stoner fundraiser needs to take place. These studies ...
03/04/2014 @ 12:29:32
By Brandon Smith
I concur, Ginamarie. I was going to say pretty much the same thing.
03/04/2014 @ 12:27:16
By Higino Alexandre
our best focus - in my opinion isn't focusing on paying for the funding for research - but freeing the system up to do the research - we need to get it out of schedule I - get it off the hit list so t...
03/04/2014 @ 12:26:30
By Ginamarie Pezzi
understanding the miraculous mechanics of how cannabinols work truly at the heart of nature's beautiful way
02/04/2014 @ 23:26:12
By Doc O'Zee
Scientists studying the benefits of cannabis are just finding out now what most pot smokers have known about for thousands of years. Of course, this is due to the prohibition of cannabis of the last 7...
02/04/2014 @ 20:48:14
By Higino Alexandre
Marijuana is a miracle plant.
02/04/2014 @ 18:46:17
By Mark Garnett


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Researchers from the University of South Carolina are exploring the potential of marijuana compounds to fight disease through gene-modifying activity.

New research suggests over-the-counter painkillers may reduce some of the side effects associated with medical marijuana, and without reducing its potential to treat conditions like Alzheimer's.

New research suggests that chemicals in marijuana may help patients who suffer from a severe form of lung disease.

A lack of training may be why most doctors still hesitate to recommend medical marijuana, according to a recent study out of Colorado.

Proposed European Union Citizens Project: LEGALIZING CANNABIS. Click here to support this initiative!

A new study suggests that a compound in marijuana could help manage pain as well as slow disease progression in patients undergoing breast cancer treatment.

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19/04/2014 @ 14.30.28
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