It stimulates the body and increases activity.

In general, the effects are stimulating and euphoric at a lower doses and more calming and narcotic at higher doses. These effects are noticeable after 5 to 10 minutes and can last for several hours.

HERE IS THE SHOP LINK WHERE TO HAVE LEGAL PRODUCTS.

You can buy kratom in the form of herbs (cut or powder), standardized herbal extracts and resin extract. Some forms are more expensive but will require less to achieve the same effect.

Vivazen
  
Long live Vivazen! This natural drink, derived from natural sources, is formulated from a unique blend of powerful, natural herbs that combat stress to provide long-lasting relaxation and enjoyment.

Kratom Malaysia (Mitragyna speciosa)
 
The effects of Kratom leaves from Malaysia can be stimulating or sedative, depending on the quantity.

Kra Thum Khok (Mitragyna hirsuta) extract 50x
A highly concentrated Kra Thum Khok (Mitragyna hirsuta) extract. Kra Thum Khok is closely related to Mitragyna speciosa and has a similar effects. This extract has a particularly strong soporific effect.

HERE IS THE SHOP LINK WHERE TO HAVE LEGAL PRODUCTS.

Fly High Amsterdam e-liquid
If there's one thing the Dutch are known for, it's the legend of the Flying Dutchman. Fly High e-liquid for electronic cigarettes lets you create an entirely new myth thanks to the stimulating & relaxing effects from kratom. Fly as high as a Dutchman!

Source: http://azarius.net/smartshop/kratom/?a=788

For thousands of years human beings have used mushrooms to transcend ordinary waking consciousness and contact the gods. Nowadays shrooms are amongst the most popular items sold in smartshops. 

Here you will find different magic mushroom grow kits for home growing. You don't need a lot of space or special lighting equipment. There are ready-to-grow kits for beginners to which just need to add a little water, and kits for experienced growers which allow you to choose the mushroom spore strain yourself. All our grow kits include detailed instructions so you can start growing your own shrooms at home in no time!

HERE IS THE LINK TO BUY.

Mushroom Grow Kit 'Master'
  
For bumper harvests! The Grow Kit Master is based on a simple and proven cultivation method. Contains all necessary materials to grow 1 kilo of fresh magic mushrooms, except for the spores. This kit can be used to grow almost any cubensis variety.

Mushroom Grow Kit 'Ready-To-Grow' XL

The XL version of the Ready To Grow kits is just as easy to use as other grow kits based on the same method, but it yields up to a massive 1 kilo in magic mushrooms. All that's required is water and a little bit of patience.

The XL mushroom grow kit contains mycelium from the Psilocybe cubensis mushroom. The mycelium in this box has been developed on a rye-based substrate with a layer of vermiculite on top.

XL mushroom grow kit features

Extra large 2100 cc cultivation box
Produces multiple harvests
Yield: up to 1000 g
From start to harvest: 3 weeks

Mushroom Grow kit 'Easy' Cambodian
  
Ready-to-grow in 3 x 5 minutes. This cubensis grow kit contains all necessary materials to grow your own magic mushrooms. Included: spore syringe, Mushbag with sterilized rye, vermiculite, perlite, filterbag, filterbox and growing instructions.

Mushroom Grow Kit 'Easy' Ecuador
  
Magic mushroom growing made easy. Contains all materials to prepare a ready-to-grow cultivation box in 3 easy steps. Requires minimum care once set-up. All you need to do is water the kit once and wait for the mushrooms to grow.

HERE IS THE LINK WHERE TO BUY THE PRODUCTS.

Magic Mushroom Grow kit 'Easy' Thai
 
Go from spores to a ready-to-grow cultivation box in just 3 steps. From then on your work is almost done. Just add water to the growbox and wait until the magic mushrooms start growing. It’s that easy!

Mushroom Grow kit 'Easy' B+
This magic mushroom grow kit provides all necessary materials to grow your own shrooms in three steps. Requires very little maintenance once set-up. Add water once, put the kit in the grow bag and wait for the shrooms to pop-up.

Source: http://azarius.net/smartshop/magic-mushrooms/grow-kits/?a=788

As you noticed already, in Windows 8 you did not find IE in the Programs and Features so you can downgrade it like you did in Windows 7 and still test and use websites and interfaces that in IE8 won't work...

What do I do to still use Internet Explorer 8 instead of IE 11? Our blog, for example, requires IE8 for the citizen journalists that post their original articles free of charge on our dBlog Open Source CMS. If you have any other version of the Microsoft Corporation's browser like IE 9 or 10, the HTML Editor (visual WYSIWYG) just will not load.

So, you want to know how to emulate any other older version of the IE browser?

First, you have to open Internet Explorer in desktop mode and press F12 to bring up the Developer Tools at the bottom of the page.

How to open Internet Explorer 11 in Desktop Mode on Windows8? Well, the desktop mode gives you visible tabs, the address bar and easy access to the IE options. Contrary to the Desktop mode is the New User interface (Metro mode), called a Chromeless mode because it uses all the screen and is without borders. From within the New User Interface, to pass to the Desktop Mode, go to Control Panel (just start typing it), and select Internet Options. Go to the Program tab, and from the drop down box, choose how you open links: Let Internet Explorer decide, Always in Internet Explorer or Always in IE on the desktop.

In the Developer Tools, after pressing F 12, down on the left you will search for the Emulation (Ctrl+8) Tab. Just select Document mode: 8 and the USer agent string: Internet Explorer 8.

Of course, you can emulate as a User agent string: Internet Explorer 10, 9, 7 and 6, IE10 - Windows Phone 8, IE9 - Windows Phone 7, IE - Xbox One, IE - Xbox 360, Google Chrome, Mozilla Firefox, Opera, Apple Safari (iPad) and Big Bot. As Document mode you can choose: Edge, 10, 9, 8, 7 and 5.

That's all folks!

Arturo Find for TurismoAssociati.it

Researchers at the Medicinal Chemistry Institute of the Spanish National Council for Research (CSIC) believe a class of chemicals found in marijuana, called cannabinoids, hold promise in improving the lives of Alzheimer's patients.

The team, led by Concepción Pérez, PhD, explained last month in the European Journal of Medicinal Chemistry why cannabinoids are "very attractive candidates" for new treatments.

Cannabinoids act on specific pathways in the brain called cannabinoid receptors, which are responsible for the effects of marijuana. According to the team, previous studies on the role of cannabinoids in Alzheimer's suggest a number of benefits.

Between the two cannabinoid pathways, CB1 activity seems to preserve cognitive function while CB2 activity may help protect and repair the brain.

"Taken together, these results suggest that CB1 receptor agonists may interrupt the mechanism of excitotoxicity and CB2 receptor agonists may suppress neuroinflammation and lead to plaque removal."

Cannabinoids can target not only the endocannabinoid system, they note, but other disease-related systems as well.

The most widely prescribed drugs today help boost levels of acetylcholine, with the assumption that a lack of acetylcholine underlies Alzheimer's. However, these drugs have proven to be ineffective.

More current research instead points to chronic inflammation as the cause of Alzheimer's.

The team is currently working on developing CB2 agonists that can prevent the build-up of beta-amyloid plaque in the brain – a key marker of the disease.

The build-up of plaque is believed to block neuron signaling and trigger cell death through inflammation.

Likewise, researchers in the U.S. have identified cannabinoids as promising candidates for preventing inflammation in Alzheimer's.

Gary Wenk, PhD, a professor of neuroscience, immunology and medical genetics at Ohio State University, told TIME that in his 25 years of researching ways to combat brain inflammation, "cannabinoids are the first and only class of drugs that have ever been effective."

Source: LeafScience

Published in the American Journal of Public Health, a group of economics researchers found that medical marijuana laws led to a sharp drop in suicide rates among young men.

The results seem to support the belief that marijuana can be used to cope with stressful life events, says study co-author Daniel Rees, PhD, professor of economics at the University of Colorado Denver.

"In keeping with what advocates of medical marijuana would argue, that is, if you're depressed, if you have to cope with a stressful situation, marijuana actually helps."

Rees notes that some research suggests marijuana works as an anti-depressant, but the evidence isn't conclusive. On the other hand, medical marijuana laws have also been linked to less alcohol consumption – particularly among young men.

Less alcohol consumption following medical marijuana legalization could also explain the drop in suicide rates, he says.

But the study was the first time researchers have looked at medical marijuana laws and suicide rates. Rees believes more research needs to be done to be sure.

"The relationship really does seem to exist. But we don't have a lot to say about mechanism."

Rees, along with co-authors D. Mark Anderson of Montana State University and Joseph Sabia of San Diego State University, compared changes in annual suicide rates between 1990-2007 of states that legalized medical marijuana and states that did not.

Suicide rates seemed to decline overall among the 12 states that passed laws during this period. But the only statistically significant decrease was in men 20-39 years old.

The team's previous research has also shown a strong correlation between medical marijuana laws and reduced traffic fatalities.

No sources of funding were reported

Source: LeafScience

The use of marijuana as a medicine remains controversial, yet marijuana's active ingredient is regularly prescribed in both Canada and the U.S.

In fact, pills that contain THC, like Marinol (dronabinol) and Cesamet (nabilone), are often recommended as substitutes for marijuana.

But while it's easy to think of the treatments as equal, research highlights some important differences.

Time of Onset
A study conducted last year at the New York State Psychiatric Institute was the first ever to compare a THC pill, dronabinol, with smoked marijuana for managing pain.

In the study, smoking a joint took full effect within 15 minutes. Dronabinol, on the other hand, took 60-90 minutes to reach its peak.

As Florida physician Dr. Heather Auld points out in a recent article, a shorter time of onset is better for pain patients.

Duration of Effect
While marijuana and dronabinol performed about the same in pain reduction, the study found dronabinol's effect to last longer.

In this case, experts say a longer-acting treatment is preferable.

Dose Flexibility
The biggest advantage of smoking marijuana is the ability for patients to self-adjust dose. Due to the shorter time of onset, patients can easily adjust dosing by taking additional puffs when necessary.

On the other hand, the delay in onset of THC pills, combined with their extended action, makes it difficult and dangerous for patients to self-adjust dose.

Studies show that both smoked marijuana and dronabinol suffer from inconsistent bioavailability, which also makes it difficult for doctors to predict dosing. This makes the flexibility offered by smoking even more beneficial.

Also, while it might be inconvenient to roll a joint every couple hours, vaporizers are widely preferred by doctors, and provide an easier way for patients to take marijuana throughout the day.

Side Effects
A study concluded that patients get just as high from taking dronabinol as they do from smoking a joint.

On the other hand, some believe dronabinol's delay in onset could make it less subject to abuse.

Source: LeafScience

Marijuana's active ingredient is a chemical called THC, which is thought to trigger psychosis in certain individuals. However, research shows that another compound in marijuana called CBD (cannabidiol) may counteract THC's effect, and could even have antipsychotic properties of its own.

In the latest study, published in the journal Neuropsychopharmacology (second LINK HERE - TA note), Dutch and British researchers reviewed more than 66 past studies on CBD and psychosis, and concluded that the compound offers a number of advantages over current drugs.

"Given the high tolerability and superior cost-effectiveness, CBD may prove to be an attractive alternative to current antipsychotic treatment."

The authors point out that CBD, unlike a vast majority of medicines, appears to have no noticeable side effects and no lethal dose. Several lines of evidence, including animal and human studies, also support its effectiveness as an antipsychotic medicine.

One of the most promising studies was published in 2012. The study involved 39 people with schizophrenia, 20 who were given CBD and 19 who were given the antipsychotic drug amisulpride.

At the end of the four-week trial, those who received CBD showed the same levels of improvement as those who received amisulpride. But more importantly, CBD did not cause the hormonal and weight imbalances that amisulpride did.

"The results were amazing," said Daniel Piomelli, Ph.D., a professor of pharmacology at the University of California-Irvine who co-authored the study.

"Not only was (CBD) as effective as standard antipsychotics, but it was also essentially free of the typical side effects seen with antipsychotic drugs."

Unfortunately, despite raising excitement among others in the field, Dr. Piomelli's findings have yet to be followed up. According to PsychCentral, barriers include CBD's relationship to marijuana and the fact that it is a naturally-occurring compound, which makes it harder to patent as a new drug.

The authors of the latest study say that larger trials are necessary in order to bring the medicine to patients.

On the other hand, to get around the patenting issue, they note that identifying the source of CBD's antipsychotic properties "could also lead to the design of new synthetic agents" that mimic its benefits.

The study received funding from the Netherlands Organization for Scientific Research

Source: LeafScience

University of Arizona Cancer Center member Dr. Mark Pagel will receive a $2 million grant from the National Institutes of Health to study the effectiveness of personalized baking soda cancer treatment for breast cancer. In other words, clinical trials on the use of oral baking soda (sodium bicarbonate) for breast cancer treatments are about to start![1] Obviously there are people in the know who have understood that sodium bicarbonate, that same stuff that can save a person’s life in the emergency room in a heartbeat, is a primary cancer treatment option of the safest and most effective kind.

Of course I feel vindicated for everything I wrote in Sodium Bicarbonate – Rich Man's Poor Man's Cancer Treatment, which still stands as the only full medical review on the subject of using simple baking soda in the practice of medicine. When taken orally with water, especially water with high magnesium content, and when used transdermally in medicinal baths, sodium bicarbonate becomes a first-line medicinal for the treatment of cancer, kidney disease, diabetes, influenza and even the common cold. It is also a powerful buffer against radiation exposure, so everyone should be up to speed on its use. Everybody’s physiology is under heavy nuclear attack from strong radioactive winds that are circling the northern hemisphere.

Actually it is no surprise that a University of Arizona researcher received this grant because there has been cancer research going on for years there. Dr. Robert J. Gillies and his colleagues have already demonstrated that pre-treatment of mice with baking soda results in the alkalinization of the area around tumors. The same researchers reported that bicarbonate increases tumor pH and also inhibits spontaneous metastases in mice with breast cancer.[2] It also reduces the rate of lymph node involvement.

I recently published about fungal infections, and breast cancer has been found to be associated with increased frequency of mold-fermented cheese consumption.[3] Fungi produce toxic metabolites called mycotoxins[4] that can cause cancer. Aflatoxin is a mycotoxin with carcinogenic potency that is found in inferior peanut butter and other nut and dairy products. Researchers in 1993 examined human breast cancer tissue and found significant carcinogenic aflatoxin within the cancer tissue implicating aflatoxin and thus fungus as a cause of breast cancer.[5]

The pH level of our internal fluids affects every cell in our body. Chronic over-acidity corrodes body tissue, and if left unchecked will interrupt all cellular activities and functions. In other words, over-acidity interferes with life itself. It is at the root of cancer.

Sodium bicarbonate medical treatments are the time honored method to "speed up" the return of the body’s bicarbonate levels to normal. Sodium bicarbonate happens to be one of our most useful medicines as it treats the basic acid-alkaline axis of human physiology.

Baking Soda and PH Medicine

The pH of our tissues and body fluids is crucial and central because it affects and mirrors the state of our health or our inner cleanliness. The closer the pH is to 7.35-7.45, the higher our level of health and wellbeing. Staying within this range dramatically increases our ability to resist acute illnesses like colds and flues as well as the onset of cancer and other diseases. Keeping our pH within a healthy range also involves necessary lifestyle and dietary changes that will protect us over the long term while the use of sodium bicarbonate gives us a jump-start toward increased alkalinity.

The pH scale is like a thermometer showing increases and decreases in the acid and alkaline content of fluids. Deviations above or below a 7.35-7.45 pH range in the tightly controlled blood can signal potentially serious and dangerous symptoms or states of disease. When the body can no longer effectively neutralize and eliminate the acids, it relocates them within the body's extra-cellular fluids and connective tissue cells directly compromising cellular integrity. Conversely when the body becomes too alkaline from too much bicarbonate in the blood, metabolic alkalosis occurs, which can lead to severe consequences if not corrected quickly.[6]

Jon Barron presents a way of looking at pH that opens up one of the major benefits of alkaline water:

Hydrogen ions tie up oxygen. That means that the more acid a liquid is, the less available the oxygen in it. Every cell in our body requires oxygen for life and to maintain optimum health. Combine that with what we know about hydrogen ions and we see that the more acid the blood (the lower its pH), the less oxygen is available for use by the cells. Without going into a discussion of the chemistry involved, just understand that it's the same mechanism involved when acid rain "kills" a lake. The fish literally suffocate to death because the acid in the lake "binds up" all of the available oxygen. It’s not that the oxygen has gone anywhere; it's just no longer available. Conversely, if you raise the pH of the lake (make it more alkaline), oxygen is now available and the lake comes back to life. Incidentally, it's worth noting that cancer is related to an acid environment (lack of oxygen)—the higher the pH (the more oxygen present in the cells of the body), the harder it is for cancer to thrive.

Understanding this is important for two reasons: (1) it reveals one of the primary benefits of alkaline water—more "available" oxygen in the system and (2) it explains why alkaline water helps fight cancer.

The ocean, the mother of all life, has an average pH of about 8.1. The ideal pH for blood sits at about 7.4, slightly alkaline—not acidic.
- Jon Barron

Barron concludes:

If you’re eating well and living cleanly, then yes, you want to drink water with a naturally occurring pH only slightly above neutral. However, if you are eating the typical Western diet, high in meat, grains, sodas, and sugars that acidify the body, then you have a different problem. Your pH balance is now so far out of normal that you must go beyond normal in the other direction to counter it. My recommendation for daily drinking water pH is about 7.5-8—depending on how acid forming your diet is. Long-term consumption of higher pH water should be reserved for special circumstances. The most famous mountain waters in the world, waters renowned for their healing properties, are highly alkaline. I’m referring to the waters coming down from the Himalayas, and specifically to the waters of the Hunza Valley, which have a pH that runs between 9 and 11.

One does not have to be a doctor to practice pH medicine. Every practitioner of the healing arts and every mother and father needs to understand how to use sodium bicarbonate. Bicarbonate deficiency is a real problem that deepens with age so it really does pay to understand and appreciate what baking soda is all about.

[1] Baking Soda Might Have Potential Against Cancer: http://digitaljournal.com/article/323645

[2] http://www.ncbi.nlm.nih.gov/pubmed/19276390

[3] One sample study is by Le, et al. (1986), in a French case-control study of 1,010 breast cancer cases and 1,950 controls with nonmalignant diseases, found that breast cancer was found to be associated with increased frequency of mold fermented cheese consumption.

[4] Going, et al. (1990) found that weddellite (calcium oxalate) crystals are present in calcifications found in the breast tissue of patients with breast cancer. Calcium oxalate crystals are formed when calcium binds with oxalic acid. Oxalic acid is a mycotoxin that can be produced by a number of different fungal species. Some fungi produce such large amounts of oxalic acid that they are used for commercial production of chemicals. Aspergillus niger fungal infection in human lungs produces large amounts of oxalic acid.

[5] Researchers examined human DNA from a variety of tissues and organs to identify and quantify aflatoxin DNA-adducts. Such adducts are considered to be proof of the mycotoxin’s presence in a particular tissue.Their finding? "Tumor tissues had higher aflatoxin-adduct levels than did normal tissue from the same individual."

[6] http://www.nlm.nih.gov/medlineplus/ency/article/001183.htm

Source: drsircus

The push to study cannabidiol, a non-psychoactive cannabis compound, as a treatment for children with severe epilepsy has finally led to clinical trials. Approved by the FDA, the studies will take place at five medical centers across the U.S., including the University of California, San Francisco (UCSF).

But contrary to earlier reports, researchers say only this month are studies on Epidiolex, a purified form of CBD, actually beginning.

The problem, as UCSF researcher Joseph Sullivan explained to KRCB Radio, is that federal law treats CBD the same way as all forms of marijuana, presenting significant legal barriers to medical research.

"There is no psychoactive or abuse potential of pure cannabidiol, yet it's treated as if it's any other type of marijuana with high THC levels."

Because of this, Sullivan and his colleagues at UCSF had to satisfy strict requirements, such as undergoing extensive background checks and purchasing a $3,000 safe, in order to start testing the drug.

And while medical marijuana advocates have shown support for the development, Dr. Sullivan seems to think researchers would be better off if they hadn't.

"Because of the current political climate – although it is changing – it tarnishes the effort to align it with medical marijuana, as opposed to just saying that this is cannabidiol. I think it's not positioning us well to get this medication out into the appropriate studies, so we understand what role it can play for us."

But considering how long studies on CBD have existed, it's uncertain whether progress would've been made if parents of epileptic children hadn't drawn attention to the issue.

Parents' Push

Since 2012, major media sources such as CNN have reported success stories of parents of severely epileptic children, who found CBD-rich cannabis to be the only treatment that worked.

What's more, according to another member of the UCSF team, Dr. Catherine Jacobson, the company behind Epidiolex hadn't planned on testing the drug for epilepsy in the first place.

It wasn't until a parent contacted GW Pharmaceuticals seeking an alternative to CBD products available at local dispensaries, Dr. Jacobson told Leaf Science, that the company began to consider Epidiolex for treating seizures.

"They got interested in the pediatric epilepsy population because one parent in California got fed up with finding cannabidiol-enriched cannabis from dispensaries. From pot growers. She got fed up because it was impossible to find. It was a very inaccurate method for treating a child with severe seizures."

Before joining the team at UCSF, Dr. Jacobson worked at Stanford University, where she compiled data from parents who had tried CBD-rich marijuana as a treatment for their children.

Published last year, her study showed that most parents (83% of those surveyed) found CBD-rich marijuana effective at reducing seizure frequency, even when other drugs couldn't.

But despite the positive findings, Dr. Jacobson agrees with her colleague's message that more research is needed in order to determine the true promise of CBD.

While she believes CBD will work for some, Dr. Jacobson told KRCB that the "hype" around CBD-rich marijuana may not be accurate, and it's unlikely that cannabidiol can cure all forms of epilepsy.

Source: KRCB via LeafScience

Marijuana has never been linked to an overdose death, and new findings may explain why.

Published in the journal Science, French researchers have identified a natural hormone that reverses marijuana intoxication in rats.

In an interview with WebMD, study author Dr. Pier Vincenzo Piazza explained that rats exposed to THC showed a dramatic rise in a brain hormone called pregnenolone. The hormone also seemed to prevent marijuana's intoxicating effects.

"When the brain is stimulated by high doses of THC, it produces pregnenolone – a 3,000 percent increase – that inhibits the effects of THC."

But the study, originally meant for developing a treatment for cannabis addiction, has been met with different interpretations.

While the authors say that an addiction treatment based on pregnenolone could soon be tested in humans, others believe the study explains how the brain protects itself from a marijuana overdose.

By binding to cannabinoid receptors, THC triggers the release of pregnenolone, which in turn weakens THC's action on the receptors – a negative feedback loop that could prevent marijuana users from getting too high.

Considering the low rates of cannabis addiction, Mitch Earleywine, a professor of psychology at the University at Albany, SUNY, adds that a drug for cannabis abuse may not even be necessary.

"Although the authors pitch this as a novel way to treat cannabis abuse, it's actually a superb – if partial – explanation for why cannabis appears to have no potential lethal dose and why its capacity for creating addiction is more like caffeine's than that of any illicit drug."

Scientists have been studying pregnenolone since the 1940s for conditions like stress and arthritis, but only recently has the hormone caught the attention of cannabis researchers.

While pregnenolone pills are sold as supplements, Dr. Piazza and his team are now working on how to deliver the hormone in higher doses.

Source: WebMD via LeafScience