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The cannabinoid that could erase decades of work is beta-caryophyllene (BCP). BCP is found in the essential oils of a variety of plants, including rosemary, hops, cloves and, of course, cannabis. It's also highly present in black pepper.

While BCP was first synthesized in 1964, it wasn't until 2008 that a group of German and Swiss scientists, led by Andreas Zimmer, Ph.D and Ildiko Racz, Ph.D of the University of Bonn, discovered that BCP is a cannabinoid.

And not just any cannabinoid, but one that acts specifically on the body's CB2 cannabinoid pathways. On the other hand, the pathways responsible for the marijuana high, CB1 receptors, aren't affected by BCP. Writing in the journal Proceedings of the National Academy of Sciences (PNAS), they summarized:

"Here, we report that the widespread plant volatile â-caryophyllene (BCP) selectively binds to the CB2 receptor and that it is a functional CB2 agonist. Intriguingly, BCP is a common constituent of the essential oils of numerous spice and food plants and a major component in Cannabis."

Interestingly, scientists have been trying to develop a viable synthetic cannabinoid that targets only CB2 receptors for a very long time.

Many now exist, and research has shown the promise of CB2-selective cannabinoids in combating many inflammatory disorders, ranging from arthritis and bladder cystitis to multiple sclerosis and HIV-associated dementia. And all without the marijuana high.

But Dr. Racz and Dr. Zimmer's latest study, published last month in the journal European Neuropsychopharmacology, shows that BCP produces similar anti-inflammatory effects. Although the study was only done in mice, they found that BCP given orally was more effective than injections of the synthetic CB2 cannabinoid JWH-133.

This, they note, suggests that BCP could indeed be a superior medicine than synthetics. Not to mention, it's widely available as a food.

"It is likely that BCP belongs to a group of common plant natural products with major potential impact on human health. The oral intake of this dietary cannabinoid with vegetable food could be advantageous in the daily routine clinical practice over synthetic cannabinoid agonists."

Unfortunately, although still in its early stages, the discovery of BCP and its potential to eliminate synthetics sets a dangerous precedent. Frankly speaking, modern medicine isn't too friendly with the idea of plants replacing pills. And medical marijuana makes for a great example.


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Subject matter:
A European solution to a European issue: legalizing cannabis. The ECI Weed like to talk aims at making the EU adopt a common policy on the control and regulation of cannabis production, use and sale.

Main objectives:
There is currently a heterogeneous legal map as regards cannabis policies in the EU. The question of coherence and discrimination is worth asking. A common policy on the control and regulation of cannabis production, use and sale would: (a) ensure equality before the law and non-discrimination of all EU citizens; (b) protect consumers and monitor health security; (c) end cannabis trafficking. Let's leap toward the legalization of cannabis and the harmonization of national legislations accross the EU.

Information on this proposed initiative is available in the following languages:

European Commission registration number:

Date of registration:

Click here to support this initiative

Web address of this proposed citizens' initiative in the European Commission's register:

Names of registered contact persons:

E-mail addresses of registered contact persons:,

Names of the other registered organisers:

Website of this proposed citizens' initiative (if any):

To support a European Citizens' Initiative, you must be an EU citizen (national of an EU member state) and be old enough to vote in European Parliament elections (18 except Austria where the voting age is 16).
For more information on the rules and conditions for the European Citizens' Initiative:

Click here to support this initiative

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You are a little shepherd boy, taking part in the qualifying rounds for the Annual Sheep Herding competitions. You must take all your sheep into the fence before the time (for each level) expires. You steer the shepherd with your mouse. Look out for all those dangerous things over there. If any of your sheep would die you will need to replay the level. Good luck!

Little Shepherd: Take part in the sheep herding competition and guide your sheep safely into the fences.

Controls: Mouse.

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Dr. Sisley is both a practicing physician and a clinical faculty member at the University of Arizona College of Medicine. In an interview with Medical Marijuana 411, she explains that – unlike traditional treatments – medical marijuana appears to relieve a wide range of PTSD symptoms.

"The truth is that marijuana can treat the whole spectrum of PTSD symptoms with this one medication."

She says many high-ranking veterans are starting to speak up about the benefits of marijuana. The only problem is, most of the evidence is anecdotal.

Dr. Sisley has spent the last three years trying to get approval for a study involving medical marijuana. But with marijuana still classified as a Schedule I substance, research on the plant seems next to impossible to conduct.

On the other hand, recent evidence has come from studies involving isolated marijuana chemicals, and programs in other countries like Israel. But closer to home, research on marijuana for PTSD continues to lag.


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By Admins (from 02/04/2014 @ 09:04:52, in z - Games Giochi Jocuri, read 1410 times)


Ice Castle Blaster: Demolish the castles in front of you using your catapult. Time to blast some ice castles!

Controls: Mouse: Hold left click to charge, release to fire.

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As marijuana has become more popular as both a medicine and recreational drug, it continues to receive protest from those concerned about its alleged dangers.

These people tend to leave out an important fact: Marijuana has yet to be recorded as a direct cause of death. Not one, as the FDA has confirmed.

On the other hand, this visual from Take Part shows just how dangerous legal drugs can be.

Indeed, it becomes hard for anyone to defend keeping marijuana illegal, once you realize that society’s most popular prescription drugs and recreational substances are actually far deadlier.

Source: - Infographic by Take Part

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Dincolo de faptul ca oferind ai posibilitatea sa primesti de pe lucruri gratis, sunt cateva motive pentru care a oferi este un beneficiu in sine.

Iata cateva dintre ele:

Faci loc.

De multe ori dupa ce iti cumperi ceva nou nu stii ce sa faci cu lucrul mai vechi, pentru ca, chiar daca nu-ti mai trebuie, e pacat sa-l arunci, cat timp inca mai e bun. Asa se face ca il depozitezi undeva, sperand ca vreodata o sa iti mai trebuiasca. Si asa apar debaralele pline cu lucruri bune dar iesite din uz, pe care cu parere de rau tot trebuie sa le arunci cand este prea inghesuiala.

Ei bine, acum poti sa le oferi, stiind ca exista cineva care cu siguranta nu le ia ca sa le tina in debara, ci chiar le va folosi, asa cum ai facut si tu.

Reciclezi/ Green.

Nu trebuie sa fii mare ecologist ca sa iti dai seama cata risipa se face in societatea noastra de consum, in care rareori asteptam ca ceva sa se strice pentru a-l inlocui.

Suntem incurajati sa consumam, sa ne cumparam varianta imbunatatita, mai la moda, mai noua, a aproape fiecarui lucru din cate exista.

Cel mai bun exemplu sunt hainele, unde de cele mai multe ori aruncam vechile haine nu pentru ca s-au rupt, ci pentru ca s-au demodat, sau nu ne mai plac, chiar daca sunt aproape noi. A fi la moda nu numai in ceea ce priveste hainele, cat si tehnologia, aceasta este dorinta multora dintre noi.

Din pacate pe termen lung tot noi suferim, consumand inutil de mult resurse, poluand natura si lasand maldare de gunoaie in urma. Ca sa diminuam cat de cat efectele consumului excesiv, putem macar sa reciclam lucrurile care mai pot fi folosite.

Ajuti pe cineva.

Fie ca ii vedem sau nu, sunt multi oameni care nu-si permit sa-si cumpere nici macar strictul necesar. Ceea ce tu nu mai folosesti pentru ei este foarte util, si in felul asta ii ajuti, dandu-le lucruri pe care altfel ar fi trebuit sa dea bani.

“Dar din dar se face rai”.

Aceasta este o lege universala de bun simt, pe care stim ca o stii, chiar daca uneori se intampla sa o uitam. De aceea ti-o reamintim, mai ales ca traim intr-o lume care incurajeaza putin cam mult egoismul.

Fii ZEN - Pregateste schimbarea.

Pentru ca lucrurile noi sa apara in viata ta, este necesar sa le faci loc. Unde este imbacseala si inghesuiala, nu prea poate sa mai incapa nimic. Doar acolo unde este spatiu se pot aduna lucruri bune. A face loc este atat un act spiritual, de purificare, cat si unul fizic, concret, de improspatare, curatare.

Astfel, cand ai loc si in interior si in exterior, pregatesti schimbarea in viata ta. Sau macar traiesti intr-un mediu mai aerisit, in care ai spatiu sa te desfasori.

E cool!

Ai ajuns pe un site care iti place atat de mult. Cat de fain este sa poti sa primesti lucruri pe gratis? Pentru ca sistemul sa functioneze, si sa ai acces la tot mai multe produse, trebuie sa ajuti sistemul sa creasca. Poti face asta ori promovand site-ul in randul prietenilor/cunoscutilor, fie oferind lucruri, care vor atrage pe site vizitatori noi, care la randul lor vor sustine sistemul.

Iti vin in minte si alte motive? Impartaseste-le cu restul comunitatii LucruriGratis: scrie aici un comentariu in care sa ne spui de ce oferi tu ceva gratuit.


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You are able to control where wind blows. Use the mouse cursor to define wind direction. Your goal is to prevent the paratroops landing on your island. Sometimes, the mighty Gods send you the items for help: cut the parachute cords; grab the paratroopers aside; sink the paratroopers.

Island Defense: Prevent the paratroopers landing on your island. Cut the parachute cords, grab them aside, and sink em!!!

Controls: Mouse.

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When it comes to consuming marijuana, the options are vast. Besides rolling a joint, there are a range of pipes and water bongs available on the market. Of course, cannabis can also be used to make various foods and drinks. Topicals and tinctures are popular among medical users as well.

Yet many doctors stand by vaporizers as the ideal method of consuming marijuana. In fact, in Israel, where medical marijuana is legal, vaporizers can be found in hospitals and senior homes. The popular Volcano Medic Vaporizer is also an approved medical device in Canada and the EU.

Here are some major reasons why vaporizers have become so popular among doctors and patients.

1. Lung Health

The effect of vaporizing on the lungs is perhaps the strongest argument for using a vaporizer.

Doctors have long been wary about the use of marijuana as a medicine because of the potential risks of smoking anything. While it's true that smoking marijuana has not been proven to cause lung cancer, the combustion of marijuana still produces several known carcinogens and tar, which can irritate the lungs and lead to chronic bronchitis.

Vaporizers were mainly designed to overcome this issue. By heating marijuana at a lower temperature than combustion, the devices produce an inhalable vapor that still contains the active medical ingredients in marijuana (cannabinoids), but without the harmful by-products.

Vaporizing cannabis is said to remove approximately 95% of the smoke that is inhaled. What's more, vaporizing has been suggested to increase the yield of anti-inflammatory terpenoids that protect the lungs from irritation.

Research also suggests that switching to a vaporizer can reverse respiratory symptoms caused by traditional methods of cannabis intake.

2. Dosing Requirements

Another advantage of vaporizers is the efficiency of converting plant matter into active cannabinoids.

A collaborative study conducted by California NORML and MAPS found that vaporizers could convert 46% of available THC into vapor, whereas the average marijuana joint converted less than 25% of THC.

Likewise, patients ranked vaporizers as the most efficient method of marijuana intake – requiring a lower dose than smoking, edibles and tea – in a recent study published in the Journal of Psychoactive Drugs.

So while vaporizers may be seen as a luxury to some, even the most thrifty marijuana users have realized that the higher efficiency of these devices can eventually offset their initial cost.

3. Side Effects

In the same patient study, vaporizers ranked highest in side effect satisfaction, meaning that patients felt most functional after vaporizing cannabis.

While the study did not investigate specific side effects, some say that vaporizers produce a more clear-headed 'high' due to the lack of smoke inhaled. Cannabis vapor can also be inhaled in short and shallow puffs, whereas other smoking devices may require taking deeper and larger breaths, which can be uncomfortable for novice marijuana users.

Of course, how one reacts to marijuana differs widely from person to person, so vaporizers may not be ideal for everyone. Ultimately, consulting with a healthcare professional and careful experimentation is the best way to figure out what method of marijuana intake is best for you.


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Instructions: your goal is to land accurately right on the platform. Control your ship with the arrow keys. You can slightly increase or decrese the descending of the ship with the up arrow key. Remember, slow down during landing! Good Luck...!!!

Go Green Go: Control your UFO and clear all the levels by landing it accurately on the destination platforms in least possible time.

Controls: Keyboard Arrow keys.

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Hi, it's Nathan!Pretty much everyone is using voice search with their Siri/Google/Alexa to ask for services and products now, and next year, it'll be EVERYONE of your customers. Imagine what you are ...
15/01/2019 @ 17:58:25
By Nathan
Now Colorado is one love, I'm already packing suitcases;)
14/01/2018 @ 16:07:36
By Napasechnik
Nice read, I just passed this onto a friend who was doing some research on that. And he just bought me lunch since I found it for him smile So let me rephrase that Thank you for lunch! Whenever you ha...
21/11/2016 @ 09:41:39
By Anonimo


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