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In 1974, Erno Rubik, a Hungarian architecture professor, invented the puzzle now famed as the Rubik's Cube.

The standard 3x3x3 version has colored faces made of 26 smaller colored blocks attached to an internal pivot.

The object is to rotate the blocks until each face of the cube is a single color.

The cube's popularity has sparked many competitions - some emphasize speedy solving, while others require participants to solve it blindfolded.

What did Rubik initially want to call his invention?

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Beta-caryophyllene is present in the essential oils of various plants including rosemary, hops, black pepper and cannabis. Like most terpenes, beta-caryophyllene contributes to the unique aroma associated with plant oils.

But in 2008, German researchers discovered that beta-caryophyllene also acts as a cannabinoid by binding to marijuana pathways in the body.

Although some compounds like THC activate both cannabinoid pathways — CB1 and CB2 receptors — beta-caryophyllene specifically targets the CB2 receptor, which does not produce a high.

"The results also support the involvement of the CB2 receptor"

Interestingly, a new study conducted with mice suggests that beta-caryophyllene may be useful in treating anxiety and depression. The findings were published online in the journal Physiology & Behavior.

"The present study has clearly demonstrated the anxiolytic and anti-depressant effect of â-caryophyllene and its underlying mechanism in a CB2 receptor-dependent manner in rodents," wrote the authors, a team of scientists with the United Arab Emirates University.

"The results also support the involvement of the CB2 receptor in the regulation of emotional behavior and suggest that this receptor could be a relevant therapeutic target for the treatment of anxiety and depressive disorders."

Previous studies have also demonstrated a role of CB2 receptors in reducing anxiety and depression, the team adds.

On the other hand, CB1 receptors, which are more widely dispersed in the brain, are known to exert a ‘biphasic' effect when it comes to anxiety and depression. Studies show cannabinoids that target CB1 receptors can help at low doses, while high doses seem to make things worse.

A better understanding of beta-caryophyllene's properties, however, may help explain why cannabis users often cite relief of anxiety and depression as reasons for their use.

According to a 2013 report in Trends in Pharmacological Sciences, "epidemiological studies have indicated that the most common self-reported reason for using cannabis is rooted in its ability to reduce feelings of stress, tension, and anxiety."

Source: LeafScience

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Scientists in the UK have now traced marijuana's ability to prevent the growth and spread of cancer to specific pathways found in tumor cells, known as cannabinoid receptors.

Dr. Peter McCormick of the University of East Anglia (UEA)'s School of Pharmacy explained the findings to Medical News Today:

"THC, the major active component of marijuana, has anti-cancer properties. This compound is known to act through a specific family of cell receptors called cannabinoid receptors."

The study, published last month in the Journal of Biological Chemistry, showed that injecting THC into mice with implanted tumors caused the cells to kill themselves — a process known as autophagy.

It also slowed the growth of tumors in breast and brain cancer cell lines.

While anecdotal reports have suggested that marijuana can fight cancer in some patients, Dr. McCormick notes that pharmaceutical companies have focused on developing synthetics and that the actual mechanisms remain "poorly understood."

But Dr. McCormick hopes his team's discovery will help speed along the development of new cancer treatments.

"By identifying the receptors involved we have provided an important step towards the future development of therapeutics that can take advantage of the interactions we have discovered to reduce tumor growth."

Previous research had already linked the anti-cancer effects of THC to the CB1 receptor, which is the most common cannabinoid pathway found in the body. CB1 receptors, when activated by THC, are also responsible for the marijuana high.

However, the group showed for the first time that CB2 receptors and GPR55 receptors are also involved, lending further evidence that marijuana can treat various cancers by acting through more than one pathway.

Still, Dr. McCormick believes patients shouldn't treat themselves with marijuana just yet.

"Cancer patients should not use cannabis to self-medicate, but I hope that our research will lead to a safe synthetic equivalent being available in the future."

It may not be only THC in the plant that fights cancer, though.

A 2013 study by a team at St. George's, University of London identified six different compounds in cannabis with anti-tumor properties including cannabidiol (CBD), cannabigerol (CBG) and cannabigevarin (CBGV).

Source: LeafScience

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Copii si familie: CINTECE COPII aplicatie Windows Phone Sistem Operativ GRATUITA!

*** Amintiti-va sa apasati "..." pentru a alege "Refresh" si "Go to Source" in Zona cu Detalii sau Video!

*** Puteti utiliza de asemenea "..." pentru a da "Share", "Read" sau "Pin to Start" oricarui obiect din aplicatie!

DESCARCA GRATUIT ACUM.

This app is designed to engage children through a series of upbeat songs and colorful animations. All our songs will have lots of characters and these nursery rhymes will entertain kids all over the world.

*** Remember to press "..." to choose "Refresh" and "Go to Source" on the Video Details Area!

*** You can also use "..." to "Share", "Read" or "Pin to Start" an object of the application!

Aceasta aplicatie a fost creata de catre ® TurismoAssociati.it/dBlog  - Educate Yourself with Information © CC - Atribuire - Necomercial - Distribuie in acelasi mod. Navigati sau descarcati aplicatiile noastre gratuite & certificate pentru Windows Phone: http://bit.ly/1tl68yf

Trebuie să vă conectati cu un cont Microsoft pe telefon inainte de a putea obtine aplicatii din Magazin Windows Phone.

DESCARCA GRATUIT AICI.

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71 de retete de salate delicioase si usor de pregatit. Alege salata ta si in cel mai scurt timp vei fi laudat la masa. Fiecare reteta vine cu lista de ingredinte, sosuri, instructiuni de preparare si fotografia color a salatei realizate. Pur si simplu divin de te lingi pe mustati! Toate retetele au fost incercate si sunt recomandate de Ratatouille.

DESCARCA AICI.

*** Amintiti-va sa apasati "..." pentru a alege "Refresh" si "Go to Source" in Zona cu Detalii sau Video!

*** Puteti utiliza de asemenea "..." pentru a da "Share", "Read" sau "Pin to Start" oricarui obiect din aplicatie!

DESCARCA GRATUIT AICI.

Aceasta aplicatie a fost creata de ® TurismoAssociati.it/dBlog  - Educate Yourself with Information © CC - Atribuire - Necomercial - Distribuie in acelasi mod. TurismoAssociati.it/shop.html

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By Admins (from 08/12/2014 @ 07:04:00, in en - Global Observatory, read 684 times)

Classic free horror and monster movies.
...horror, terror, affright, dread, fright, fearfulness, dismay, nightmare...

"The movie will begin in five moments," the mindless voice announced. All those unseated will await the next show. We filed slowly, languidly into the hall. The auditorium was vast and silent. As we seated and were darkened, the voice continued, "The program for this evening is not new. You've seen this entertainment through and through. You've seen your birth, your life and death. You might recall all the rest. Did you have a good world when you died? Enough to base a movie on?"

DOWNLOAD LINK HERE.

Free full length classic terror films.

*** Remember to press "..." to choose "Refresh" and "Go to Source" on the Video Details Area!
 
*** You can also use "..." to "Share", "Read" or "Pin to Start" an object of the application!

This app was created by ® TurismoAssociati.it/dBlog  - Educate Yourself with Information © CC - Attribution - Non Commercial - Share Alike.

DOWNLOAD LINK HERE.

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This app is designed to engage children through a series of upbeat songs and colorful animations. All our songs will have lots of characters and these nursery rhymes will entertain kids all over the world.

DOWNLOAD LINK HERE.

*** Remember to press "..." to choose "Refresh" and "Go to Source" on the Video Details Area!

*** You can also use "..." to "Share", "Read" or "Pin to Start" an object of the application!

This app was created by ® TurismoAssociati.it/dBlog  - Educate Yourself with Information © CC - Attribution - Non Commercial - Share Alike. Browse or download our free & certified applications for Windows Phone: LINK HERE.

>>>>> Remember to press "..." to choose "Refresh" and "Go to Source" on the Video Details Area!

>>>>> You can also use "..." to "Share", "Read" or "Pin to Start" an object of the application!

DOWNLOAD LINK HERE.

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--- --- ---

UPDATE:

You Tube responds on 04.12.2014 3:22 like this:

[Copyright claim] Claim released: "Discorso: John F. Kennedy e le societá segrete. TurismoAssociati.it/dBlog"

Hi Turismo Associati,

Good news! Your dispute wasn’t reviewed within 30 days, so the copyright claim on your YouTube video has now been released by SME.

    Video title: "Discorso: John F. Kennedy e le societá segrete. TurismoAssociati.it/dBlog"

Your video's monetization settings have now been restored. View monetization settings.

- The YouTube Team

--- ... ---

This means that for the last 30 days the video about JFK was censured from Google AdSense monetization! Nice...

--- --- --- --- ---

Turismo Associati has on it's You Tube account (LINK HERE) many controversial videos. One of these, named: John F. Kennedy: The Speech About Secret Societies That Assassinated Him, subtitled in italian: Discorso: John F. Kennedy e le societá segrete and in romanian with the name: Discursul lui John F. Kennedy despre societatile secrete.

It's all about the famous speech made by John Fitzgerald Kennedy on 27 of april 1961 about the secret societies and their conspiring that killed JFK. HERE IS A LINK if you want to read more about the subject.

The truth is, since May 19, 2014, less then six months ago, these three videos - made with audio from the public domain (the registration of a public speech made by the United States President J.F.K. - were systematically trolled and censured from YouTube view and Google Adsense monetization. All of them!

Let me tell you about the last problem for the italian version. We've received, yet again, another Copyright Notice.

Here are the details:

1st copyright details:
"Vendetta Kingz-Foundation Of Kingz", sound recording administered by: 0:03
The Orchard Music - Claim released.

2nd copyright details:
"Stray From The Path-Landmines", sound recording administered by: 0:05
WMG - Claim released.

3rd copyright details:
"Movus-Explosión", sound recording administered by: 0:01
SME - Your appeal is awaiting response by December 5th, 2014

As you can all find, with a simple Google search, most of the claims are installed on behalf of unknown and obscure music labels or bands with songs with lyrics like, in the case of Stray From The Path - Landmines: "But you can see me die trying, never scared of being poor/ Never bent for the rich, never gave a s**t/ When will you listen to this? You sorry son of a... Ah f**k it"...

Who has the interest on censuring this important message left by one of the most appreciated president of the U.S.?

Just think outside your box!

Arturo Find for Turismo Associati . it

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THC, or tetrohydrocannabinol, is the most recognized ingredient in cannabis. It is best known for causing the high that you get from using marijuana.

As a result, THC has also caused the most controversy surrounding the plant's medical use, with many health professionals citing the high as a drawback.

However, while compounds like cannabidiol (CBD) have started to gain favor due to their lack of psychoactivity, decades of research have revealed a number of medical benefits unique to THC. Here is a list of 7 of them:

1. Pain Relief

One of the most common uses of medical marijuana is for pain relief. And as it turns out, THC is the ingredient in marijuana responsible for its pain-relieving effects.

Studies show that THC activates pathways in the central nervous system which work to block pain signals from being sent to the brain. Likewise, cannabis has been shown to be especially effective against neuropathic pain, or nerve-related pain.

2. PTSD

Post-traumatic stress disorder (PTSD) is another common reason to use medical marijuana. Interestingly, the high from THC is also associated with temporary impairments of memory.

While this may be seen as a drawback for some marijuana users, impaired memory is often therapeutic for those who struggle to forget painful memories, such as patients who suffer from PTSD. Recent studies confirm that oral doses of THC can help relieve a variety of PTSD-related symptoms including flashbacks, agitation and nightmares.

3. Nausea and Vomiting

THC has been available in pill form for treating nausea and vomiting in cancer patients since the 1980s.

Marinol, a pill containing synthetic THC, was the first THC-based medication to be approved by the FDA for this purpose. Since then, other THC pills have been developed and prescribed to patients undergoing chemotherapy, including a pill called Cesamet.

4. Appetite Stimulant

Along with its ability to reduce nausea, THC is known to work as a powerful appetite stimulant in both healthy and sick individuals. Similarly, Marinol and Cesamet are regularly prescribed to boost appetite in patients with cancer and HIV-associated wasting syndrome.

A number of studies conducted with Marinol suggest that THC can also stimulate weight gain in anorexia.

5. Asthma

Treating asthma may not seem like an obvious use for medical marijuana. But as it turns out, THC's ability to improve breathing in asthmatics is supported by research dating back to the 1970s.

Following trials that showed smoking marijuana could help calm asthma attacks, scientists tried (and failed) to develop an inhaler that could deliver THC. While the THC inhaler idea was ultimately abandoned, some say modern-day vaporizers might be the solution.

6. Glaucoma

Another benefit of THC recognized early on was its potential to relieve eye pressure in patients with glaucoma.

Likewise, after studies in the 1970s showed that smoking marijuana could reduce symptoms in glaucoma sufferers, scientists tried (and failed again) to develop a way to administer THC in eye drops. The idea proved too complicated due to the fact that THC is not soluble in water.

While some glaucoma patients rely on medical marijuana to this day, The American Glaucoma Society maintains the position that its effects are too short-lived (lasting 3-4 hours) to be considered a viable treatment option.

7. Sleep Aid

Many are aware of the sleep-inducing effect of marijuana, and research shows that THC is largely responsible. In fact, trials conducted in the 1970s found that oral doses of THC helped both healthy individuals and insomniacs fall asleep faster.

Interestingly, more recent studies suggest THC may also improve nighttime breathing and reduce sleep interruptions in those who suffer from a common disorder known as sleep apnea. Researchers are currently working to develop a THC-based medicine for treating the condition.

Source: LeafScience

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With a rising number of patients seeking a prescription for marijuana, clinicians are increasingly faced with the dilemma of prescribing a treatment that lacks support or recommending patients not use a medicine that could benefit them in the long-run.

Most, out of caution, end up choosing the second option.

"It's understandable that physicians might be reluctant to prescribe cannabis, because there is not a great deal of evidence about its effectiveness for many of the conditions we'd like to use it for, or about its safety," says Dr. David Juurlink, who heads the division of clinical pharmacology and toxicology at Sunnybrooke Health Sciences Centre, a University of Toronto teaching hospital.

"It's understandable that physicians might be reluctant"

But deciding not to prescribe marijuana may not be erring on the side of caution, he says.

Indeed, despite a lack of evidence for cannabis, there also isn't much evidence against it. At least compared to the variety of potent pharmaceuticals commonly prescribed for pain.

"We consider them evidence-based therapies, but they really haven't been studied and documented for many patients in a way that shows that their benefits offset their risks," notes Dr. Juurlink.

"All drugs have toxicities, whether they are plant based or come from pharmacies. It's the case that the direct toxicities of drugs for pain — like Oxycontin or Fentanyl or anti-inflammatory drugs — are simply much greater than the toxicities of cannabis."

Patients who suffer from severe pain are often treated with opioid-based medicines and non-steroidal anti-inflammatory drugs (NSAIDs). But the dangers of these drugs have become increasingly apparent and experts are urging for an end to their loose prescribing.

Recent data ranks Canada as the second highest per-capita consumer of prescription opioids, second only to the U.S. In Ontario, the rate of opioid-related deaths doubled between 1992 and 2010, now totaling about 550 deaths a year.

"You can make a case to prescribe cannabis"

NSAIDs, while less acutely fatal, are known to cause intestinal bleeding and kidney problems when taken too regularly.

But can medical marijuana be safely prescribed as an alternative to painkillers? Dr. Juurlink seems to think so.

"I think the point that physicians, and perhaps patients, can take away is that you can make a case to prescribe cannabis to select patients. Especially when the patient tells you that it works for them and when prescribing it allows the patient to reduce their use of other noxious drugs."

Source: LeafScience

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Nice read, I just passed this onto a friend who was doing some research on that. And he just bought me lunch since I found it for him smile So let me rephrase that Thank you for lunch! Whenever you ha...
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