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Neuropathic and inflammatory pain


Nociception (pain perception) is a critical mechanism of the body self-defence, inducing to discontinue a stimuli potentially deteriorating.
When pain is experienced chronically,often as a consequence of a neural or metabolic dysfunction, as in the case of neuropathic pain (NP), it is fundamental to find agents able to target the pathways producing allodynia (sensation of pain evoked by a stimulus which would not, normally, produce it) and ultimately to eradicate them. [1]
 
It has been estimated that 7-8% of the entire population of Western Countries develops neuropathic pain, which is often caused by other pathologies (cancer, diabetes, Multiple Sclerosis, HIV or stroke, just to mention a few).[2]
Despite the aetiology of the disease is multifarious, it causes the nervous system to be hypersensitised due to prolonged impulses.
 
Neuropathic pain alone is a chronic debilitating disease that affects up to 4 million people just in Europe; given the poor outcome of the medicines currently in use for the management of symptoms, (gabapentin, opioids and tricyclic antidepressant mainly) many studies are focussed on this field of study. [3]


 
Why using cannabinoids?
Phytocannabinoids have been extensively used throughout history for various therapeutic purposes, particularly analgesic. However, the cannabinoid circuitry is relatively young, with only 20 years since its first characterization by the pioneering studies of Raphael Mechoulam, whose discoveries conveyed these chemicals from traditional home remedies to pharmacological investigation. [4]
 
Since the discovery of Cannabinoid receptors pain regulation became one of the main area of study. Compelling evidence has shown that cannabinoids decrease allodynia both thermal and mechanical, proving their role for treating neuropathic pain. [5]
 
Cannabinoids vs opioids
The main mediator of the antinociceptive effect is thought to
be the cannabinoid CB1 receptor. The benefit of targeting directly CB1 receptors is endorsed by their anatomical distribution in core pain centers of the brain (Periaqueductal grey-substantia gelatinosa-medulla oblongata-dorsal horn). [6]
 
 CB1 agonists (all the drugs that activate CB1 receptors, such as THC) prevent “wind-up” phenomenon in the dorsal horn (an exaggerated sensitization to pain leading to allodynia and hyperalgesia and hallmark of neuropathic pain). (Hyperalgesia =increased sensation to pain, usually due to damaged pain receptors and nerve terminals)
It is hence crucial to pinpoint that manipulating cannabinoid circuitry is more advantageous than targeting directly opioids for the treatment of neuropathic pain. [6, 7]
 
Moreover, the medicines that activate CB1 receptors maintain their efficacy, at the opposite of morphine, which is less potent over time (so that more doses are needed, and with it, an increase in side effects).
Importantly, the spontaneous discharge (which lead to pain sensation) has been located mainly in primary afferent myelinated A-fibres, which are rich in cannabinoid receptors rather than opioids. [8]
 
The current medications for treating pain are still mainly opioids, but only approximately 50% of the sufferers finds relief with the available cures, thus highlighting how the clinic would greatly benefit from drugs oriented on cannabinoids modulation. [2]

On the ring today...

Opioids are prescribed worldwide to deal with pain.
Only recently Sativex has been approved for treatment of pain in 2 Countries only! If you want to know more click here.
Here are some facts, all the side effects, both very common and rare for both medications.
Remember that researching cannabinoids medications does not necessarly mean using THC-based medications and lots of research is going through in this direction, making cannabinoid-based drugs even safer and non-psychoactive.

 

Side effects Cannabis Morphine
    blood pressure chages
    constriction of the pupil of the eye
    irregular heart rate
  increased heart rate erectile dysfunction
Cardiovascular redness of the eyes eye or eyesight problems
  vasodilatation/facial flush facialflushing
    irregular heart rate
    oedema of the extremities
    palpitations
     
  aids sleeping difficult sleeping
Circadian somnolence sleepiness
     
  aids gastrointestinal functions (diarrhea is rare) biliary problems
Gastrointestinal anti-emetic, can cause nausea when overdosed constipation
  eases cramps gastrointestinal problems
  abdominal pain can occur (rare) indigestion
    nausea
    vomiting
    stomachpain
     
    amenorrhoea
Hormonal   decreased libido
     
    allergic reactions
    anaphylactic reactions
Immunologic anti-inflamatory itching
    skin rash or rashes
    worsening of pancreatitis
    urticaria
     
Muscolar muscle relaxant abnormal muscle movement
  unsteadiness muscle twitching
     
    confusion
    drowsiness
    headaches
    loss of appetite
    thinking problems
    weakness
  confusion convulsions
  drowsiness dysphoria- euphoria
  increased appetite fainting
  weakness feeling agitated
Neurologic euphoria general feeling of being unwell
  sense of well-being hallucinations
  depersonalization mood changes
  hallucination physical dependence
  paranoid reaction psychological dependence
    vertigo
    withdrawal symptoms
     
    bronchospasm
Respiratory bronchodilator pulmonary oedema
    respiratory depression
     
    severe dry mouth
    sweating
Salivation dry mouth renal spasms
    urinary retention


List of references:

1. Scadding, J. (2003). Neuropathic Pain.ACNR. 3 (2), 8-14.
2. Mao, J., Price, D.D., Lu, J., Keniston, L., Mayer, D.J. (2000) Two distinctive antinociceptive systems in rats with pathological pain. Neurosci. Lett., 280, 13-16.
3. Selph, S Carson, S Fu, R et al. (2011). Drug Class Review Neuropathic Pain. Available: ncbi.nlm.nih.gov . Last accessed 4/3/13 .
4. British Medical Association (1997) Therapeutic Uses of Cannabis. London, Harwood Academic Publishers
5. Fox, A., Kesingland, A., Gentrym C., McNair, K., Patel, S., Urban, L., James, I. (2001) The role of central and peripheral Cannabinoid 1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. Pain, 92, 91-100.
6. Martin, B.R., Lichtman, A.H. (1998) Cannabinoid transmission and pain perception. Neurobiol.Dis., 5, 447-461.
7. Lichtman, A.H., Martin, B.R. (1991) Spinal and supraspinal components of cannabinoid-induced antinociception. J.Pharmacol. Exp. Ther., 258, 517-523.

Author: Viola Brugnatelli, BSc Neuroscience - Source: Casey McClain at naturegoingsmart.com/

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Cannabis kills Tumor cells
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576089 http://www.ncbi.nlm.nih.gov/pubmed/20090845
http://www.ncbi.nlm.nih.gov/pubmed/616322
http://www.ncbi.nlm.nih.gov/pubmed/14640910
http://www.ncbi.nlm.nih.gov/pubmed/19480992
http://www.ncbi.nlm.nih.gov/pubmed/15275820
http://www.ncbi.nlm.nih.gov/pubmed/15638794
http://www.ncbi.nlm.nih.gov/pubmed/16818650
http://www.ncbi.nlm.nih.gov/pubmed/17952650
http://www.ncbi.nlm.nih.gov/pubmed/20307616
http://www.ncbi.nlm.nih.gov/pubmed/16616335
http://www.ncbi.nlm.nih.gov/pubmed/16624285
http://www.ncbi.nlm.nih.gov/pubmed/10700234
http://www.ncbi.nlm.nih.gov/pubmed/17675107
http://www.ncbi.nlm.nih.gov/pubmed/14617682
http://www.ncbi.nlm.nih.gov/pubmed/17342320
http://www.ncbi.nlm.nih.gov/pubmed/16893424
http://www.ncbi.nlm.nih.gov/pubmed/15026328

Cannabis Cures Colorectal Cancer
http://www.ncbi.nlm.nih.gov/pubmed/22231745
http://www.ncbi.nlm.nih.gov/pubmed/17583570

Cannabis Cures Uterine, Testicular, and Pancreatic Cancers http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4

Cannabis-derived substances in cancer therapy and anti-tumour properties.
http://www.ncbi.nlm.nih.gov/pubmed/20925645

Cannabis Cures Brain Cancer
http://www.ncbi.nlm.nih.gov/pubmed/11479216

Cannabis Cures Mouth and Throat Cancer
http://www.ncbi.nlm.nih.gov/pubmed/20516734

Cannabis Cures Breast Cancer
http://www.ncbi.nlm.nih.gov/pubmed/20859676
http://www.ncbi.nlm.nih.gov/pubmed/18025276
http://www.ncbi.nlm.nih.gov/pubmed/21915267
http://www.ncbi.nlm.nih.gov/pubmed/22776349
http://www.ncbi.nlm.nih.gov/pubmed/18454173
http://www.ncbi.nlm.nih.gov/pubmed/16728591
http://www.ncbi.nlm.nih.gov/pubmed/9653194

Cannabis Cures Lung Cancer
http://www.ncbi.nlm.nih.gov/pubmed/22198381?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/21097714?dopt=Abstract

Cannabis Cures Prostate Cancer
http://www.ncbi.nlm.nih.gov/pubmed/12746841?dopt=Abstract http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339795/?tool=pubmed http://www.ncbi.nlm.nih.gov/pubmed/22594963
http://www.ncbi.nlm.nih.gov/pubmed/15753356
http://www.ncbi.nlm.nih.gov/pubmed/10570948
http://www.ncbi.nlm.nih.gov/pubmed/19690545

Cannabis Cures Blood Cancer
http://www.ncbi.nlm.nih.gov/pubmed/12091357
http://www.ncbi.nlm.nih.gov/pubmed/16908594

Cannabis Cures Skin Cancer
http://www.ncbi.nlm.nih.gov/pubmed/12511587
http://www.ncbi.nlm.nih.gov/pubmed/19608284

Cannabis Cures Liver Cancer
http://www.ncbi.nlm.nih.gov/pubmed/21475304

Cannabis Cures Cancer in General
http://www.ncbi.nlm.nih.gov/pubmed/12514108
http://www.ncbi.nlm.nih.gov/pubmed/15313899
http://www.ncbi.nlm.nih.gov/pubmed/20053780
http://www.ncbi.nlm.nih.gov/pubmed/18199524
http://www.ncbi.nlm.nih.gov/pubmed/19589225
http://www.ncbi.nlm.nih.gov/pubmed/12182964
http://www.ncbi.nlm.nih.gov/pubmed/19442435
http://www.ncbi.nlm.nih.gov/pubmed/12723496
http://www.ncbi.nlm.nih.gov/pubmed/16250836
http://www.ncbi.nlm.nih.gov/pubmed/17237277

Cannabinoids in intestinal inflammation and cancer: www.ncbi.nlm.nih.gov/pubmed/19442536?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=22

Cannabis use and cancer of the head and neck: Case-control study:

www.ncbi.nlm.nih.gov/pmc/articles/PMC2277494

Cannabis THC at high doses in area, inhibits cholangiocarcinoma cancer:

www.ncbi.nlm.nih.gov/pubmed/19916793?itool=Email.EmailReport.Pubmed_ReportSelector.Pubmed_RVDocSum&ordinalpos=6
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
http://www.ncbi.nlm.nih.gov/pubmed/21115947

marijuana kills cancer cells
http://www.ncbi.nlm.nih.gov/pubmed/17952650
http://www.ncbi.nlm.nih.gov/pubmed/16835997
http://cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4

Cannabis Treatment in Leukemia
http://www.ncbi.nlm.nih.gov/pubmed/15978942
http://www.ncbi.nlm.nih.gov/pubmed/16754784
http://www.ncbi.nlm.nih.gov/pubmed/15454482
http://www.ncbi.nlm.nih.gov/pubmed/16139274
http://www.ncbi.nlm.nih.gov/pubmed/14692532

Cannabinoids and the immune system.
http://www.ncbi.nlm.nih.gov/pubmed/11854771
http://www.ncbi.nlm.nih.gov/pubmed/12052046

Cannibas partially/fully induced cell death in Cancer http://www.ncbi.nlm.nih.gov/pubmed/12130702
http://www.ncbi.nlm.nih.gov/pubmed/19457575
http://www.ncbi.nlm.nih.gov/pubmed/18615640
http://www.ncbi.nlm.nih.gov/pubmed/17931597
http://www.ncbi.nlm.nih.gov/pubmed/18438336
http://www.ncbi.nlm.nih.gov/pubmed/19916793
http://www.ncbi.nlm.nih.gov/pubmed/18387516
http://www.ncbi.nlm.nih.gov/pubmed/15453094
http://www.ncbi.nlm.nih.gov/pubmed/19229996
http://www.ncbi.nlm.nih.gov/pubmed/9771884
http://www.ncbi.nlm.nih.gov/pubmed/18339876
http://www.ncbi.nlm.nih.gov/pubmed/12133838
http://www.ncbi.nlm.nih.gov/pubmed/16596790
http://www.ncbi.nlm.nih.gov/pubmed/11269508
http://www.ncbi.nlm.nih.gov/pubmed/15958274
http://www.ncbi.nlm.nih.gov/pubmed/19425170
http://www.ncbi.nlm.nih.gov/pubmed/17202146
http://www.ncbi.nlm.nih.gov/pubmed/11903061
http://www.ncbi.nlm.nih.gov/pubmed/15451022
http://www.ncbi.nlm.nih.gov/pubmed/20336665
http://www.ncbi.nlm.nih.gov/pubmed/19394652
http://www.ncbi.nlm.nih.gov/pubmed/11106791
http://www.ncbi.nlm.nih.gov/pubmed/19189659
http://www.ncbi.nlm.nih.gov/pubmed/16500647
http://www.ncbi.nlm.nih.gov/pubmed/19539619
http://www.ncbi.nlm.nih.gov/pubmed/19059457
http://www.ncbi.nlm.nih.gov/pubmed/16909207
http://www.ncbi.nlm.nih.gov/pubmed/18088200
http://www.ncbi.nlm.nih.gov/pubmed/10913156
http://www.ncbi.nlm.nih.gov/pubmed/18354058
http://www.ncbi.nlm.nih.gov/pubmed/19189054
http://www.ncbi.nlm.nih.gov/pubmed/17934890
http://www.ncbi.nlm.nih.gov/pubmed/16571653
http://www.ncbi.nlm.nih.gov/pubmed/19889794
http://www.ncbi.nlm.nih.gov/pubmed/15361550

Cannabis treatment of translocation-positive rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/pubmed/19509271

Cannabis Induces apoptosis of uterine cervix cancer cells http://www.ncbi.nlm.nih.gov/pubmed/15047233

Cannabis treatment in lymphoma
http://www.ncbi.nlm.nih.gov/pubmed/18546271
http://www.ncbi.nlm.nih.gov/pubmed/16936228
http://www.ncbi.nlm.nih.gov/pubmed/16337199
http://www.ncbi.nlm.nih.gov/pubmed/19609004

Cannabis kills cancer cells
http://www.ncbi.nlm.nih.gov/pubmed/16818634
http://www.ncbi.nlm.nih.gov/pubmed/12648025

Cannabis regulator of Neural Cell Development
http://www.ncbi.nlm.nih.gov/pubmed/16787257

Cannabis treatment of Melanoma
http://www.ncbi.nlm.nih.gov/pubmed/17065222

Cannabis treatment for Thyroid Carcinoma
http://www.ncbi.nlm.nih.gov/pubmed/18197164

Cannabis treatment in Colon Cancer
http://www.ncbi.nlm.nih.gov/pubmed/18938775
http://www.ncbi.nlm.nih.gov/pubmed/19047095

Cannabinoids in intestinal inflammation and cancer. http://www.ncbi.nlm.nih.gov/pubmed/19442536

Cannabinoids in health and disease
http://www.ncbi.nlm.nih.gov/pubmed/18286801

Cannabis a neuroprotective after brain injury
http://www.ncbi.nlm.nih.gov/pubmed/11586361

Cannabis inhibits Cancer Cell Invasion
http://www.ncbi.nlm.nih.gov/pubmed/19914218

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Umberto Veronesi, da sempre a favore della liberalizzazione delle cosiddette 'droghe leggere', che interviene così sul tema sul numero del settimanale 'Oggi'.

"La marijuana fa male? Come ministro della Salute, quando ricoprii l'incarico anni or sono, mi posi anch'io questa domanda - ricorda il direttore scientifico dell'Istituto europeo di oncologia di Milano - E me la posi anche come medico e soprattutto come padre di famiglia. Ebbene, la commissione scientifica che avevo nominato concluse che i cosiddetti 'danni da spinello' sono praticamente inesistenti. Dopo quella, altre commissioni scientifiche giunsero alle stesse conclusioni. E oggi perfino l'Organizzazione mondiale della sanità ha invitato i governi a depenalizzare l'uso personale di marijuana, consapevole su dati scientifici che l'uso di spinelli non fa male".

Nella sua rubrica lo scienziato definisce "infondata anche la credenza che la marijuana dia dipendenza e apra la strada all'uso delle droghe pesanti, come cocaina e morfina. Liberalizzare lo spinello non è malinteso permissivismo, ma una posizione realistica che punta alla riduzione del danno. Risulta che metà dei nostri giovani e molti adulti fanno uso di marijuana. Ha senso criminalizzarli?".

Fonte: AdnKronos Salute

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Un passo importante, che fissa la corretta interpretazione della normativa sulle droghe. Incapaci di produrre una innovazione politica all'altezza del mutato contesto internazionale, in Italia il testo unico sulle droghe viene rivisto e riscritto dalla giurisprudenza, ieri dalla Corte di cassazione, l'altro ieri dalla sentenza con cui la Corte costituzionale ha giudicato illegittima l'intera legge Fini-Giovanardi. Potrebbero tranquillamente riferirvisi le argomentazioni usate da Stefano Rodotà su la Repubblica di domenica scorsa a proposito della procreazione medicalmente assistita: "negli ultimi venti anni la tutela dei diritti è stata garantita quasi esclusivamente dai giudici costituzionali e ordinari, mentre il Parlamento cercava di ridurne illegittimamente l'ampiezza o rimaneva colpevolmente silenzioso". Un bel paradosso e il principale dei problemi per chi, come il Ministro Orlando, voglia riformare la giustizia nel solco della distinzione di ruoli tra politica e magistratura: se la politica continua a non decidere, o a decidere in senso contrario ai vincoli posti dalla Costituzione, come pretendere che non vi sia un conflitto con una giurisdizione cui sono delegate tutte le possibilità di riconoscimento dei diritti dei cittadini?

Non altro è il problema che abbiamo posto negli ultimi vent'anni in materia di droghe, sin dal referendum del 1993, che abrogò le parti più ideologiche e repressive della legge Iervolino-Vassalli, e poi qualche mese fa, all'indomani della abrogazione della legge Fini-Giovanardi. Spetta al Parlamento riscrivere da cima a fondo la legge sulla droga, tenendo conto del fallimento della war on drugs, del mutato contesto internazionale e dei cambiamenti nell'uso delle sostanze stupefacenti. E spetta al Parlamento risolvere i problemi di carattere generale sollevati da un corretto esercizio del potere giurisdizionale. Tra questi, quello delle migliaia di persone tutt'ora in carcere in forza di previsioni penali giudicate illegittime dalla sentenza della Corte costituzionale del febbraio scorso.

La perdurante ignavia del Parlamento – interrotta solo dal tentativo revanchista della Ministra Lorenzin, di reintrodurre per decreto l'intera legge Fini-Giovanardi (norme penali comprese) – ci ha costretto a riprendere la via giudiziaria. E' possibile tollerare ulteriormente il prolungarsi dell'esecuzione di pene giudicate, nella loro misura, illegittime dalla Corte costituzionale? La Corte di cassazione ha chiaramente detto di no, ma questo non basta quando il problema sia polverizzato in migliaia di situazioni personali che richiedono ricorsi individuali al giudice dell'esecuzione, ed essendo la gran parte degli interessati privi della minima cognizione giuridica e di un'adeguata assistenza legale. Tocca allora andare città per città e carcere per carcere, a informare i detenuti e spiegare loro che possono chiedere la rideterminazione della pena e, molto probabilmente, essere scarcerati. E' quello che stiamo facendo, con i garanti dei detenuti, le camere penali e le altre associazioni che hanno aderito alla campagna "Cancellare le pene illegittime". In Friuli, dove la campagna è stata presentata alla stampa il 2 agosto scorso, potrebbero essere 262 su 644 i detenuti interessati al ricalcolo delle pene, a Ferrara 50 su 300. Interessa al Ministro Orlando e ai riformatori della giustizia e delle istituzioni questa riaffermazione in concreto di principi basilari dello stato di diritto?

Fonte: FuoriLuogo.it

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By Admins (from 07/09/2014 @ 07:08:13, in ro - TV Network, read 185 times)

Cand veti fi gata sa va ridicati, va veti ridica...

Toata puterea de care aveti nevoie este in mainile voastre.
Priviti in jurul vostru: sistemul nostru financiar a fost deturnat de generatii de hoti, in timp ce voi munciti din ce in ce mai greu pentru din ce in ce mai putin.

Jocul este trucat inpotriva voastra... ne-au transformat pe toti in sclavi.
Uitati-va in inima sistemului nostru financiar: un pret a fost stabilit pentru pretioasele noastre resurse: hrana, apa, energie, aur... insasi valoarea banilor a fost distorsionata de excroci de talie mondiala intr-o gigantica conspiratie a unei coruptii de neoprit.

Ei jefuiesc miliarde de oameni de trilioane de dolari pe an, oameni buni!
Nu e nevoie de masuri de austeritate! Nu e nevoie de suferinte financiare! Nu e nevoie de saracie! Nu exista limitari! Suntem victimele unui jaf de proportii inimaginabile! Am fost indepartati de natura care suprima simtul umanitatii!

Adevarul este ca... este mai mult decat suficient pentru a ne descurca. In urma cu 60 de ani productivitatea crestea atat de repede incat s-a preconizat ca o familie ar fi putut trai azi confortabil cu un singur venit de la un singur furnizor lucrand doar 10 ore pe saptamana.

Putem produce foarte multe bunuri economisind timp.

Ce s-a intamplat cu acel vis?

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Mehran Tavakoli Keshe, fondatorul fundatiei belgiene cu acelasi nume, inginer in fizica nucleara de origine iraniana, a facut timp de multi ani cercetari in domeniul obtinerii energiei din vidul cosmic (sau a "free energy" cum mai este denumita) si din plasma. A realizat o serie de dispozitive care ar revolutiona obtinerea energiei de orice fel pentru oamenii de pe intreaga planeta cat si transporturile de orice fel, de la cele locale pana la cele galactice, care ar "incheia" pentru totdeauna era combustibilor fosili si dictatura corporatiilor energetice mondiale. Tehnologia denumita MAGRAV se anunta astfel un prim pas catre lumea de maine, catre eliminarea programelor de control si catre manifestarea abundentei.

In anul 2012 fundatia a invitat reprezentantii tuturor statelor planetei la o conferinta in care li s-a pus la dispozitie aceasta tehnologie in mod gratuit cu conditia respectarii pacii planetare. Din 21 martie 2013 fundatia a inceput o serie de conferinte publice referitoare la aceste subiecte si la implementarea cat mai rapida a lor in viata comunitatilor.
Fundatia Keshe a lucrat mai bine de doua decenii pentru a inregistra patente in toata lumea, astfel incat atunci cand noua tehnologie va fi prezentata pe piata, sa nu fie nevoie de sume colosale pentru a putea fi folosita, deoarece intentia primara este aceea de a fi oferita in mod caritabil tuturor oamenilor de pe aceasta planeta.

Fundatia a fost inregistrata ca o organizatie non-profit in Olanda si are un birou permanent in Ninove – Belgia, iar scopul sau este dezvoltarea de noi tehnologii spatiale precum: transporturi, generarea de electricitate, sisteme de sanatate si de nutritie pentru calatoriile spatiale.
Se pare ca singurele conditii pentru ca acest pas sa fie facut erau cooperarea guvernelor si implicit a oamenilor de stiinta din fiecare tara si intentia de a folosi aceasta noua tehnologie intr-un sens benefic, ceea ce, in ciuda nivelului de constiinta mediu de pe planeta care este destul de scazut, poate deveni realitate.

Avand se pare motive sa se teama ca viata sa ar putea fi in pericol, ieri Mehran Tavakoli Keshe a acordat un interviu emisiunii Mike Harris Show la care au participat peste 3 milioane de ascultatori, iar astazi, in urma cu cateva ore, a pus la dispozitia intregii planete prin intermediul filialei din Taiwan a fundatiei, continutul legendarului stick USB cu detalii despre tehnologia MAGRAV care a fost inmanat in anul 2012 reprezentantilor mai multor state.

Iata linkurile de download:

· versiune .iso (imagine DVD): GoogleDocs
· link alternativ cu arhiva .rar: onedrive

Va recomand sa downloadati arhiva si sa dati mai departe acest mesaj astfel incat planurile acestei tehnologii sa ajunga in posesia a cator mai multi oameni, mai ales a celor care le pot pune in practica !!

Surse anunt : Facebook si
KesheFoundation

Sursa : inspatelescenei

Concluzie:

Cu ceva vreme inainte am publicat articole despre anunturile facute de catre Mehran Keshe cu privire la proiectele umanitare pe care le-a conceput pentru umanitate, astfel incat sa ne eliberam de sclavia energetica a actualului sistem corupt al cabalei ( articolele le gasiti pe blogul meu la categorii, Fundatia Keshe ). Dupa cum observam la momentul actual viata ii este pusa in pericol si a facut publica documentatia pentru construirea unor reactoare cu plasma la rece si nave cosmice cu propulsie nucleara. Probabil aceste documente daca ajung la un grup de cercetatori, finantat de catre o entitate binevoitoare si progresista sau de catre un stat care doreste binele propriului popor si natiuni, le poate pune in aplicare si saltul va fi enorm. Chiar si din concurenta alte multe state ar urma rapid sa implementeze aceste tehnologii si beneficiul la nivelul populatiei ar fi enorm.

Speram ca aceasta trecere la noile tehnologii sa se faca cat mai rapid si in mod cat mai pasnic cu putinta !
   
Daca nu puteti downloada din linkurile expuse incercati aici : RichardPresser

Drum drept spre Lumina !

Sursa: Burebista2012

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Drinking Raw Cannabis Juice Cures BRAIN TUMORS - LEAF Documentary.

We just finished the english caption of the entire documentary. Please, help translate it in all the languages of the world so the people would know the truth about the magic of cannabis: dotsub . Join us on: DotSub subtitling group - facebook and on our website: http://www.TurismoAssociati.it/dBlog

It is no secret that our world is seeing a huge increase in poor health and cancer cases. It should come as no surprise when we look at what we eat daily, the condition of our environment and the types of body care products we use daily that contain a ton of cancer causing agents. Mainstream medicine suggests that chemotherapy and radiation are the best means to go about treating cancer, but there is a growing body of evidence to suggest there exist much better cures.

Cannabinoids may very well be one of the best disease and cancer fighting treatments out there. If you have heard of Rick Simpson you have heard of his methods of preparing cannabis or hemp in such a way where he is able to extract the oil from it and use that oil to treat cancer. Rick has been very successful in his work and his popularity is growing as a result. At the same time, he has received a great deal of flack for his methods as they pose a serious threat to the business that is cancer.

What are cannabinoids?
Cannabinoids refer to any of a group of related compounds that include cannabinol and the active constituents of cannabis. They activate canbinoid receptors in the body. The body itself produces  compounds called endocannabinoids and they play a role in many processes within the body that help to create a healthy environment. Cannabinoids also play a role in immune system generation and re-generation. The body regenerates best when it’s saturated with Phyto-Cannabinoids. Cannabinoids can also be found in Cannabis. It is important to note that the cannabinoids are plentiful in both hemp and cannabis. The differentiation between hemp and cannabis is simply that hemp only contains 0.3% THC while cannabis is 0.4% THC or higher. (Technically they are both strains of Cannabis Sativa.)

Cannabinoids have been proven to reduce cancer cells as they have a great impact on the rebuilding of the immune system. While not every strain of cannabis has the same effect, more and more patients are seeing success in cancer reduction in a short period of time by using cannabis. Contrary to popular thought and belief, smoking the cannabis does not assist a great deal in treating disease within the body as therapeutic levels cannot be reached through smoking. Creating oil from the plant or eating the plant is the best way to go about getting the necessary ingredients which are the cannabinoids. Another aspect of smoking the cannabis that must be looked at is the fact that when the cannabis is heated and burnt it changes the chemical structure and acidity of the THC which changes its ability to be therapeutic. Further, anytime you burn something and inhale it, you create oxidation within the body. That oxidation is not healthy for the body and can lead to health issues itself.

Cannabinoids can prevent cancer, reduce heart attacks by 66% and insulin dependent diabetes by 58%. Cannabis clinician Dr. William Courtney recommends drinking 4 – 8 ounces of raw flower and leaf juice from any Hemp plant.

Cannabis – whether Sativa, Indica, Ruderalis, male, female, hermaphrodite, wild, bred for fiber, seeds or medicinal resin – is a vegetable with every dietary essential we can’t synthesize: Essential Amino Acids, Essential Fatty Acids, Essential Cannabinoid acids and hundreds of anti-Cancer compounds. It is important to note that when we isolate to important compounds of cannabis and take them in supplement we miss out of the bio-synergistic compounds that go along with it in full plant form. This makes it more difficult for the body to determine what exactly it is taking in.

“If you heat the plant, you will decarboxylate THC-acid and you will get high, you”ll get your 10 mg. If you don’t heat it, you can go up to five or six hundred milligrams & use it as a Dietary Cannabis. . . and push it up to the Anti-oxidant and Neuro-protective levels which come into play at hundreds of milligrams,” stated Dr. William Courtney.


The Endocannabinoid System (ECS) maintains our biological systems by regulating each cell tissue. It uses Arachadonic acid/Omega 6 to make Endo-Cannabinoids: fatty molecules that communicate harm between cells. Dietary Cannabis mimics the ECS by providing Cannabinoids when there is an Arachadonic acid deficiency or Clinical Cannabinoid Deficiency.

Doctors who have been researching cannabis and it’s benefits in diet for some time have recommended that people make cannabis a part of their everyday diet. To reiterate, the plant does not need to contain high levels of THC and it can simply be hemp. Eating Cannabis that does contain THC will not get you high. Also, smoking it does not give the same results as eating or juicing the plant. If we view the plant simple as a vegetable like all other vegetables we eat, it makes sense that we wouldn’t put it inside rolling papers and smoke it to get the nutritional benefits.

Sources: collective-evolution
rawhemp
phoenixtears
cannabisinternational
edrv.endojournals.org

cannabisclinicians

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By Admins (from 04/09/2014 @ 08:10:33, in en - Science and Society, read 178 times)

You would think that with the latest Operating System from Microsoft, Windows 8, it would be easy to connect a smartphone with Windows Phone OS. Think again.

It looks like Windows complicated the things, making it very difficult to manage a device. If you open the Manage Bluetooh devices (opening Search with Windows Key and Q and looking for Bluetooth), after you turn on Bluetooth you'll get: Your PC is searching for and can be discovered by Bluetooth devices... that will never stop searching. And furthermore, sometimes, just sometimes, you'll get the Pair Devices option to recognise the phone and pc.

If you're lucky to see the Pair option, it's partially OK. But you'll have to go to this next step:

1) open cmd (type cmd in windows search winkey+Q and open it)
2) type in fsquirt
3) a window will open that says send/receive files via bluetooth
4) enable your PC to receive files from the smartphone you connected before.

It worked for me. Please comment.

Arturo Find for http://www.TurismoAssociati.it/dBlog

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MOST IMPORTANT THING: FOR SHARING, YOU MUST USE http:// not https://

FIX YouTube Preview Not Showing On Facebook TUTORIAL.

Sometimes when posting a video from YouTube onto your Facebook Timeline or Facebook Fan Page, the YouTube video thumbnail preview doesn't show up on Facebook. Whether you just uploaded the video to YouTube, or maybe you just changed the thumbnail, or possibly it's not even your video to begin with, this is a common issue and has a super easy fix!

All you need to do is take the YouTube video URL link that you were trying to post to Facebook and paste the YouTube video link on this site: LINK HERE.

Once you've pasted the video URL there, just press the "debug" button and make sure that it pulls up a picture of the correct video thumbnail below. Once you see the thumbnail, go back to your Facebook Timeline, or Fan Page and paste the YouTube link again and it will pull up the embedded video!

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By Admins (from 02/09/2014 @ 07:02:26, in en - Video Alert, read 193 times)

We just finished the english caption of the entire documentary. Please, help translate it in all the languages of the world so the people would know the truth about the magic of cannabis: LINK  . Join us on: DotSub subtitling group - LINK .

LEAF

Approx. 106,000 Americans die yearly from prescribed medications. Source: Journal of American Medical Association

I totally believe in what we're doing and I think it's the most important thing that I can be doing right now

There are so many people who are sick and if this can help them people have to know about this.

Research is finding that there's an alternative.

It's fantastic that I have to share this with my family that we are doing this together

and that we both feel so passionately about it

Dr. William Courtney, MD: She was on over 40 different medicines, she had been on Methotrexate and Plaquenil,

one of those which nearly destroyed her vision

potent anti inflammatory Brexin

was on all sorts of painkillers and all sorts of antibiotics

she had classic steroid toxicity

her face was the shape of a moon because there is a lot of swelling that occurs in the face

At the age of 16 she was diagnosed with juvenile rheumatoid arthritis that evolved into a lupus condition

with diagnose of interstitial cystitis and autoimmune disorder, in bed for 4 years

her mother thought she would never survive

Kristen began juicing using raw cannabis leaves.

I went to talk to William as a friend and as a doctor

about his experience with patients and how they used cannabis

Seeing what the juicing did for me, using it in this form was so significant, it changed my life.

U.S. DEPARTMENT OF JUSTICE finding:

"In strict medical terms marijuana is far safer than many of the foods we consume."

About 4 to 6 weeks after I started on juicing everyday I had no more back pain,

I didn't need pain pills, I felt the best day I ever had.

A lot of people think cannabis and pot are not medicine

The SCIENCE

I stumbled on an article in Scientific American, december 2004

they had an article on marijuana as The Brain's Own Marijuana and introduced the idea

that the body produces compounds that are very similar to those found in marijuana or cannabis

Cannabis actually goes up stream, it provides feedback from the postsynaptic nerve

to the presynaptic nerve which is unheard in neurochemistry where

all neurotransmissions were unidirectional and all of the sudden swimming

against that force a little cannabinoid molecule that tied the hole system together.

The phytocannabinoids from this plant augment the body's attempt to restore

and increase function to a normal level.

So it mimics the regulatory system of cellular physiology

and recently the Food and Drug Administration has approved of CBD

which is a cannabinoid like THC, one of 80 cannabinoids.

The federal patent compares vitamin C, vitamin E and CBD or cannabidiol.

CBD turned out to be more potent than either of those two.

Non Psychoactive

...thing that I warn my patients out is

if you're going to be juicing this flower and this leaves you're going to be doing this high dose,

non psychoactive, cannabinoid dietary approach, please do not heat it.

When you heat cannabis you make it psychoactive which for a large part of the community

the psychoactivity of a plant is the measure of its medical quality but its really quite the inverse.

To heat cannabis in any way you're destroying some of the medicinal proprieties of it

To use the plant effectively we have to use it the way it evolved over 34 million years,

which is raw, because when is raw the THC is bonded as THC acid

it requires aging, drying, so as a hunter-gatherer we gather this plant, we know as well

as this plant ages it changes character and suddenly has a psychoactive effect.

Dr. Brett Wright, M.D.: I think that's the most exciting area of cannabis research:

is looking at non psychoactive cannabinoids.

Because if you do heat it you'll decarboxylate the THC acid and you're going

to have 600 mg of THC acid with the CBD acid and be unconscious probably the better part of the week.

Between heating the plant whether that's in a sucker, a cookie or baked good, butter,

vaporized, smoked, all those techniques convert THC acid which is not psychoactive into THC

and provide you with that 10 mg dose,

but if you eat the plant raw then THC acid is the way is found in the plant and not psychoactive.

The juicing allows to get up to the 500 to 600 mg which is 60 times more than you can tolerate if it was heated.

This treatment is not psychoactive where people would have to be stoned when they take it

they can take it and go to work and play with their kids

It's hard for me to understand the laws against something like green leaf therapy

and to think that Prednisone is legal.

We're still fighting the stigma of marijuana back from the 20-30-40-50's

The Controversy

Attorney Keith Failder, Former Prosecutor: I was a prosecutor for 8 years in Mendocino County so I know it

it from both as a defense attorney and as a prosecutor that the 1972 Controlled Substances Act

said that marijuana had no medical value whatsoever

But the Government has a Patent on its medical proprieties,

the Food and Drug Administration has approved that it is investigated as a drug...

I have not found the United States to be very open about cannabis research.

In order to print an article in a journal you have to use cannabis that they certified for your study

and there are physicians who waited 3-4-5-6 years, some even longer then that to just get a sample.

The Federal Government has been kind of schizophrenic in the way it looks at marijuana:

it says it has no medical value under that act but at the same time

the Federal Government has been funding research on marijuana for years and decades and

even patented certain strains of marijuana because they recognized it has its medical value.

The California Narcotic Officers' Association does not believe in Medical Marijuana,

they believe it's all a big scam and that's how they train law enforcement officers.

Law enforcement is allowed to take a percentage of all assets that are forfeited and seized

under the state and federal asset forfeiture law,

so it takes the really enlightened passion of law enforcement officer to recognize that they use

the Medical Marijuana laws are designed to protect patients.

Tom Allman, Mendocino County Sheriff: I was trained: when somebody had marijuana you took them to jail.

It was no medicine. The use for marijuana as an illegal substance and the people went to jail for.

In 1996 California took a huge leap. I didn't support Proposition 215 because of the education I had,

the experience I had and what I've seen through the illegal marijuana gardens that I've seen throughout my career.

Since 1996 I have changed my opinion somewhat: I believe there is a very clear medicinal use for marijuana,

that being said I believe that there are a large percentage of people who use marijuana as an excuse

to either make profits or for recreation. The people who use marijuana for the true intended use

that the voters passed, medicinal, I'll do anything I can to support their rights.

Proposition 215 (or the Compassionate Use Act of 1996) is a California law concerning the use of medical cannabis. It was enacted, on November 5, 1996.
There's many more things that law enforcement can be focused on than Medicinal Marijuana.

I don't want to give the impression at all that I support people who are growing marijuana

for medical purposes 364 days of the year and then 1 day a year they make a big sale for a couple of hundred

thousands dollars and they are commercial sellers a day of the year. They are the people that are causing

problems for the people who really and truly need and can use medical marijuana.

Baby Amber 2 years old - Diagnosed with terminal brain tumors

Terrified! When you're told as a parent that your child does have a tumor in her brain. It took 24 hours

in an operating room, they gave us a 10 percent chance of survival with treatment.

Arlene Casen - Hospice Coordinator, 30 years experience: The Oakland Children's Hospital where they called me

and they said they had a baby who they were discharging home, this baby had completed all treatments

that would be useful for it had brain tumors

had surgery, had radiation and chemo and the tumors were still growing, still multiplying and therefore they

said to the parents: just take this baby home and make it comfortable because there's nothing more that

we know that would help its condition.

...it's hard to accept to the point where they wanted us to take her and try to find some acceptance

A month went by and I got in contact with the family and they said: well, we just got back from

the children's hospital, they did a CT scan, the tumors had shrunk and there are fewer of them

and they said: I'll tell you what we've been doing, we've been juicing the fan leaves of the marijuana plant

and given to our baby a shot glass of this juice everyday.

This is like this wonderful hospice story that she's no longer on hospice,

I brought the oxygen concentrator back. It's just one of those wonderful success stories.

You know, the plant is a pretty amazing plant because it appears

that the juice of this plant is saving this baby's life.

Here we have something that can really change people's lives

I mean I was laying in bed catheterized thinking that, physicians were just trying to make me comfortable,

they really didn't think that there was anything more that they could do,

and: I mean I lived to be 30, which I am now...

That was the best I could hope for...

the best I could hope for was taking enough Methadone and Percocet everyday that I just didn't feel anything at all.

Mary Ellen Jerkovich-Director Humboldt Patient Resource Center: I've been long in touch with Doctor Courtney

because we have received a doctor's recommendation from one of his patients and in it: as they start juicing


So after I contacted him I was really excited to hear that there might be

some other alternatives to smoking the cannabis.

These are friends we had the past year, they said: your father is not the same as he was when we first met him,

he seems to be much more alive, doing a lot more, more active.

And I have informed them it was because of the juice he had been taking.

Right after we start juicing he seemed to be more active, we would do things out in the garage more

and he wouldn't spend so much time in his chair.

We have run out periodically in the last year and a half and that's what made me convince that he needed it,

because when he ran out he would have trouble to get out of the car.

I had four doctors tell me that I should have a hysterectomy.

You either have no ovaries or at very least you're sterile.

...I wouldn't be able to have a child

Despite the very potent birth control, despite being sterile, a baby decided to come join the party.

We like to distinguish ourselves while being extremely scientific and people know that if they're gonna come

to us they're going to go through a lot of hoops but they're also going to get the most up-to-date scientific

knowledge on this subject and they are going to see a physician who is an expert in the field

of non psychoactive cannabinoids and there are plenty of people that want that and are looking for that.

We opened our fifth office in Luxembourg, their government is really sympathetic and open

There's an international group studying autism and CBD in Luxembourg

There is a physician there who is writing cannabis scripts who is also a senator

The Government is actually funding experiments in a research center using cannabis in large part because

of Dr. Courtney's work with non psychoactive cannabinoids and senator Colombera's work with cancer patients.

There are now facilities for testing of plants and there's been more progress made in the last 5 or 6 months,

a new strain in from Spain called "Cannatonic", 6.9 percent CBD.

That's 700% increase over "Northern Lights" which is our previous high producer.

I would like to find strains that have all of the cannabinoids present in an amount that's useful

I'd like to produce strains that are adapted to environment

In Luxembourg we're producing thousands of thousands of thousands of seeds to raise the money

to give away half a pound of seeds, because if that person grows an acre of cannabis and feeds a family

the proteins and the fat acids

an incredible food source, an incredible preventative medicine source and an incredible therapeutic source

and at the same time they're sucking 5 times as much CO2 out of the environment as an acre of trees

First we have to change Convention Treaty no.1 which was the convention that the UN put out in 1961

that says cannabis is a crime, if you have it, if you grow it, if is in your possession you should be in prison.

That dogma has dominated the world.

Right now, they're asking for input from the World Health Organization and the process of writing a letter

stating that this is a dietary essential, it's not a criminal thing, because we have to change

that treaty before we can go into Central South-America and say:

you grow an acre of this plant, feed your family, prevent illnesses.

So, Cannabis International wants: legalizing the plant globally, giving it back to people as a food source,

prevent illness is so much better then waiting until you have disease.

With my own experience, in all the patients that I've spoken to,

I believe that it's not an isolated incident, that this is the best medication.

The producers of this film recommend that you consult with your physician before attempting to juice cannabis.

For more information visit: CannabisInternational

A film by Patrick Norris and Sergio Vasquez

Producers: Eric Stromberger, Patrick Norris, Sergio Vasquez, Dr. William Courtney, Kristen Peskuski

Caption: Ford Turani for www.TurismoAssociati.it/dBlog - Trilingual World Observatory: italiano, english, romana. GLOBAL NEWS & more...

 

 

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Ultimi commenti - Last comments - Ultimele comentarii:
Hey there I am so glad I found your web site, I really found you by acdecint, while I was researching on Askjeeve for something else, Nonetheless I am here now and would just like to say thank you for...
14/01/2015 @ 08:10:47
By o5aZW4SE
I suffer from Breast Cancer, which for me, is basically a Death Sentence on my life, the thoughts of having Breast Cancer burns and itches simultaneously in my heart that i was dead alive (and looks h...
28/11/2014 @ 21:58:30
By jessica
sir are you encouraging people participate in some kind of game? ...where people give up their power? It never worked before .... that’s why I suggest instead of give up your power, exercise it from y...
05/10/2014 @ 08:45:09
By James Smith
Asta e marihoana nu?ei cine te poate opri so faci ,eu nu prefer astfel de fistractie deoarece am vazut ca dupa nu mai faci altceva fecit ca dormi bine,nu am incercat nu incerc dar nu opresc pe nimeni ...
30/09/2014 @ 09:34:56
By Miulesvu Corina Lucia
tovaraseilor .. nu confundati un sifonar sau turnator cuun ofiter sub acoperire.. e o mare diferenta ...
29/09/2014 @ 13:07:51
By Alex Andu
... deci şi Toma e securist, logic!
27/09/2014 @ 15:49:04
By Bogdan Sith Huşanu
Mai voinicilor,voi nu stiati ca inainte de 89,securistii erau omul si copacul,,ei acum sint si mai multi,cred ca au dat si lastari,ce naiba..!..
27/09/2014 @ 15:45:01
By Toma Pasculea


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