A group of researchers from the University of Glasgow in the UK have confirmed the ability of Sativex, a medicine derived from marijuana, to relieve severe chronic pain.
The study, published online Jan. 13 2014 in the European Journal of Pain, involved over 300 patients suffering from a type of nerve pain called peripheral neuropathic pain.
Neuropathic pain is "one of the most difficult types of pain to treat," the authors say. Half of all patients fail to gain adequate relief through standard therapies.
The 15-week study was conducted at 39 different treatment centers, most of them in the UK. By the end, 28% of patients that received Sativex showed clinically-significant pain relief verses 16% that received placebo.
Patients were allowed to adjust dosing themselves, and only minor symptoms such as dizziness and nausea were reported.
Besides pain relief, the researchers observed improvements in sleep symptoms as well, which they say is consistent with prior studies involving smoked cannabis and a synthetic THC pill called Marinol (or dronabinol).
Other studies have also explained how marijuana works to ease pain. By binding to receptors at both the brain and spinal level, compounds in the plant seem to interfere with how the nervous system transmits pain.
The drug used in the latest study, Sativex, is a whole plant extract containing equal concentrations of marijuana's two main ingredients, THC and CBD, along with minor levels of various terpenes and other cannabinoids found in the plant.
The drug is made by British drug company GW Pharmaceuticals and is administered as an oral spray.
Investigators at Mount Sinai School of Medicine in New York have found evidence that cannabidiol (CBD), a non-psychoactive component of marijuana, can prevent the accumulation of fat caused by alcohol – known as fatty liver disease.
Over time, elevated fat levels in the liver can lead to more severe problems such as hepatitis and cirrhosis.
Published online Jan. 4th in the journal Free Radical Biology and Medicine, the researchers conducted the study by injecting mice with ethanol twice a day for 5 days to model the impact of binge drinking on the liver. Mice in the test group were given CBD prior to ethanol.
The results confirmed that CBD could prevent fat accumulation and other signs of liver injury. Molecular analysis pointed to multiple factors, including CBD’s anti-oxidant properties and its ability to stimulate pathways involved with fat breakdown.
The authors add that CBD can act as both an anti-oxidant and anti-inflammatory, and has been suggested to block the progression of arthritis and type 1 diabetes, among other things.
Marijuana's active ingredient is a chemical called THC, which is thought to trigger psychosis in certain individuals. However, research shows that another compound in marijuana called CBD (cannabidiol) may counteract THC's effect, and could even have antipsychotic properties of its own.
In the latest study, published in the journal Neuropsychopharmacology(secondLINK HERE - TA note), Dutch and British researchers reviewed more than 66 past studies on CBD and psychosis, and concluded that the compound offers a number of advantages over current drugs.
"Given the high tolerability and superior cost-effectiveness, CBD may prove to be an attractive alternative to current antipsychotic treatment."
The authors point out that CBD, unlike a vast majority of medicines, appears to have no noticeable side effects and no lethal dose. Several lines of evidence, including animal and human studies, also support its effectiveness as an antipsychotic medicine.
One of the most promising studies was published in 2012. The study involved 39 people with schizophrenia, 20 who were given CBD and 19 who were given the antipsychotic drug amisulpride.
At the end of the four-week trial,
those who received CBD showed the same levels of improvement as those who received amisulpride. But more importantly, CBD did not cause the hormonal and weight imbalances that amisulpride did.
"The results were amazing," said Daniel Piomelli, Ph.D., a professor of pharmacology at the University of California-Irvine who co-authored the study.
"Not only was (CBD) as effective as standard antipsychotics, but it was also essentially free of the typical side effects seen with antipsychotic drugs."
Unfortunately, despite raising excitement among others in the field, Dr. Piomelli's findings have yet to be followed up. According to PsychCentral, barriers include CBD's relationship to marijuana and the fact that it is a naturally-occurring compound, which makes it harder to patent as a new drug.
The authors of the latest study say that larger trials are necessary in order to bring the medicine to patients.
On the other hand, to get around the patenting issue, they note that identifying the source of CBD's antipsychotic properties "could also lead to the design of new synthetic agents" that mimic its benefits.
The study received funding from the Netherlands Organization for Scientiﬁc Research
L'unico accorgimento, per evitare di incappare in una denuncia penale, è compilare un modulo e consegnarlo alle forze dell'ordine. Ad investire sulla cannabis è stato anche Antonino Chiamonte, un agricoltore di Mendicino in provincia di Cosenza, che ha sostituito le foglie di marijuana al grano, ormai "non più conveniente per i prezzi troppo alti". Dai mattoni della bioedilizia per costruire case ai vestiti, passando gli alimenti, gli olii e persino i cruscotti delle auto, la sua canapa viene destinata agli stabilimenti per la produzione di diversi oggetti.
Secondo i dati di 'Assocanapa', in Calabria gli agricoltori di cannabis sono già una decina ed in costante aumento in tutta Italia, con piantagioni in 400 ettari di terreni al nord e 450 al sud del Paese. "Lavoro anche come assistente sociale - spiega Antonino Chiamonte, 46 anni - ma dall'anno scorso ho deciso di coltivare cannabis nel mio ettaro di terreno e per ogni piantagione guadagno 1.300 euro". Chiamonte ha piantato i semi un anno fa e subito dopo ha comunicato ai carabinieri di avere la piantagione di cannabis a scopo industriale. Un'orto insolito che fa gola a più di una persona. "Ogni tanto qualcuno si intrufola tra le piante per portarne via una - aggiunge - tanto che sono stato costretto a mettere un cartello dalla scritta: 'Se volete una piantina non strappatela, ve la regaliamo'".
La canapa da fibra prodotta da Chiamonte viene lavorata in uno stabilimento a Taranto e servirà in un cantiere di Brindisi per costruire "la prima abitazione 'a base di cannabis' in Italia". Per ora, invece, l'unico stabilimento autorizzato a produrla a scopo farmaceutico è Rovigo. "La canapa è un ottimo investimento per tanti usi - spiega ancora l'agricoltore - rigenera i terreni, non necessita di diserbanti ed ha ottimi costi. Quella importata dall'Olanda costa anche di più. E allora perché non avviare una grande produzione in Italia? E' ingiusto criminalizzarla e finora la legislazione ne ha compromesso gli utilizzi associandola solo alla droga. In passato ho fumato qualche spinello, lo considero comunque molto meglio di devianze come alcol o droghe pesanti".
Ed ora grazie ai guadagni del "piccolo tesoro" nell'orto di casa sua, Chiamonte ha messo in piedi un'azienda agricola per farne una fattoria sociale dove ospitare i bambini autistici a fare ippoterapia con gli asinelli. Dalla cannabis alla solidarietà, per "sfatare un tabù".
Now that recreational marijuana has been legalized a whole new breed of tourist are visiting Colorado. It's pretty easy to acquire marijuana, however, finding 420 friendly accommodations is not so easy. It is not legal to smoke in public so don't try smoking in the parks or on the sidewalks. Here are a few things to consider when planning your cannabis vacation in Colorado.
1. Stay at a hotel that allows pot smoking. How do you know if a hotel is 420 friendly? Pick up the phone, call the front hotel, and ask. Be blunt (pun intended). If they say no then keep calling. Hotels have the right to decide if they wish to allow smoking, so you can be kicked out if you stay somewhere that doesn't allow it. Many of the large chains are going to say no.
2. Private residences. There are scores of locals who rent out a 420 friendly room for a reasonable rate. You can find these places through classifieds such as craigslist. Be very careful if you choose to go this route. Security is important so if a situation doesn't feel right then bail.
3. Camping and smoking weed legally is more difficult that you think. State parks are a big no no, and national parks are obviously out. This leaves private campground and many have policies against marijuana. Again, if you plan to camp you may want to call ahead. *Many Coloradans claim that many campsites have policies against marijuana, but it is often tolerated as long as you are discrete about it. Use your best judgement, and stay out of state parks and federal land.
4. Do not smoke in a car. It doesn't matter if the car was parked or not. This can easily cause confusion which could possibly lead to you getting into some trouble.
5. Perhaps give edibles a try. They are much more discrete and can be consumed in any hotel room. If you have not done edible before then be very careful to take an appropriate dosage.
The laws are constantly changing, and can vary between cities. Always perform due diligence.
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University of Arizona Cancer Center member Dr. Mark Pagel will receive a $2 million grant from the National Institutes of Health to study the effectiveness of personalized baking soda cancer treatment for breast cancer. In other words, clinical trials on the use of oral baking soda (sodium bicarbonate) for breast cancer treatments are about to start! Obviously there are people in the know who have understood that sodium bicarbonate, that same stuff that can save a person’s life in the emergency room in a heartbeat, is a primary cancer treatment option of the safest and most effective kind.
Of course I feel vindicated for everything I wrote in Sodium Bicarbonate – Rich Man's Poor Man's Cancer Treatment, which still stands as the only full medical review on the subject of using simple baking soda in the practice of medicine. When taken orally with water, especially water with high magnesium content, and when used transdermally in medicinal baths, sodium bicarbonate becomes a first-line medicinal for the treatment of cancer, kidney disease, diabetes, influenza and even the common cold. It is also a powerful buffer against radiation exposure, so everyone should be up to speed on its use. Everybody’s physiology is under heavy nuclear attack from strong radioactive winds that are circling the northern hemisphere.
Actually it is no surprise that a University of Arizona researcher received this grant because there has been cancer research going on for years there. Dr. Robert J. Gillies and his colleagues have already demonstrated that pre-treatment of mice with baking soda results in the alkalinization of the area around tumors. The same researchers reported that bicarbonate increases tumor pH and also inhibits spontaneous metastases in mice with breast cancer. It also reduces the rate of lymph node involvement.
I recently published about fungal infections, and breast cancer has been found to be associated with increased frequency of mold-fermented cheese consumption. Fungi produce toxic metabolites called mycotoxins that can cause cancer. Aflatoxin is a mycotoxin with carcinogenic potency that is found in inferior peanut butter and other nut and dairy products. Researchers in 1993 examined human breast cancer tissue and found significant carcinogenic aflatoxin within the cancer tissue implicating aflatoxin and thus fungus as a cause of breast cancer.
The pH level of our internal fluids affects every cell in our body. Chronic over-acidity corrodes body tissue, and if left unchecked will interrupt all cellular activities and functions. In other words, over-acidity interferes with life itself. It is at the root of cancer.
Sodium bicarbonate medical treatments are the time honored method to "speed up" the return of the body’s bicarbonate levels to normal. Sodium bicarbonate happens to be one of our most useful medicines as it treats the basic acid-alkaline axis of human physiology.
Baking Soda and PH Medicine
The pH of our tissues and body fluids is crucial and central because it affects and mirrors the state of our health or our inner cleanliness. The closer the pH is to 7.35-7.45, the higher our level of health and wellbeing. Staying within this range dramatically increases our ability to resist acute illnesses like colds and flues as well as the onset of cancer and other diseases. Keeping our pH within a healthy range also involves necessary lifestyle and dietary changes that will protect us over the long term while the use of sodium bicarbonate gives us a jump-start toward increased alkalinity.
The pH scale is like a thermometer showing increases and decreases in the acid and alkaline content of fluids. Deviations above or below a 7.35-7.45 pH range in the tightly controlled blood can signal potentially serious and dangerous symptoms or states of disease. When the body can no longer effectively neutralize and eliminate the acids, it relocates them within the body's extra-cellular fluids and connective tissue cells directly compromising cellular integrity. Conversely when the body becomes too alkaline from too much bicarbonate in the blood, metabolic alkalosis occurs, which can lead to severe consequences if not corrected quickly.
Jon Barron presents a way of looking at pH that opens up one of the major benefits of alkaline water:
Hydrogen ions tie up oxygen. That means that the more acid a liquid is, the less available the oxygen in it. Every cell in our body requires oxygen for life and to maintain optimum health. Combine that with what we know about hydrogen ions and we see that the more acid the blood (the lower its pH), the less oxygen is available for use by the cells. Without going into a discussion of the chemistry involved, just understand that it's the same mechanism involved when acid rain "kills" a lake. The fish literally suffocate to death because the acid in the lake "binds up" all of the available oxygen. It’s not that the oxygen has gone anywhere; it's just no longer available. Conversely, if you raise the pH of the lake (make it more alkaline), oxygen is now available and the lake comes back to life. Incidentally, it's worth noting that cancer is related to an acid environment (lack of oxygen)—the higher the pH (the more oxygen present in the cells of the body), the harder it is for cancer to thrive.
Understanding this is important for two reasons: (1) it reveals one of the primary benefits of alkaline water—more "available" oxygen in the system and (2) it explains why alkaline water helps fight cancer.
The ocean, the mother of all life, has an average pH of about 8.1. The ideal pH for blood sits at about 7.4, slightly alkaline—not acidic. - Jon Barron
If you’re eating well and living cleanly, then yes, you want to drink water with a naturally occurring pH only slightly above neutral. However, if you are eating the typical Western diet, high in meat, grains, sodas, and sugars that acidify the body, then you have a different problem. Your pH balance is now so far out of normal that you must go beyond normal in the other direction to counter it. My recommendation for daily drinking water pH is about 7.5-8—depending on how acid forming your diet is. Long-term consumption of higher pH water should be reserved for special circumstances. The most famous mountain waters in the world, waters renowned for their healing properties, are highly alkaline. I’m referring to the waters coming down from the Himalayas, and specifically to the waters of the Hunza Valley, which have a pH that runs between 9 and 11.
One does not have to be a doctor to practice pH medicine. Every practitioner of the healing arts and every mother and father needs to understand how to use sodium bicarbonate. Bicarbonate deficiency is a real problem that deepens with age so it really does pay to understand and appreciate what baking soda is all about.
 One sample study is by Le, et al. (1986), in a French case-control study of 1,010 breast cancer cases and 1,950 controls with nonmalignant diseases, found that breast cancer was found to be associated with increased frequency of mold fermented cheese consumption.
 Going, et al. (1990) found that weddellite (calcium oxalate) crystals are present in calcifications found in the breast tissue of patients with breast cancer. Calcium oxalate crystals are formed when calcium binds with oxalic acid. Oxalic acid is a mycotoxin that can be produced by a number of different fungal species. Some fungi produce such large amounts of oxalic acid that they are used for commercial production of chemicals. Aspergillus niger fungal infection in human lungs produces large amounts of oxalic acid.
 Researchers examined human DNA from a variety of tissues and organs to identify and quantify aflatoxin DNA-adducts. Such adducts are considered to be proof of the mycotoxin’s presence in a particular tissue.Their finding? "Tumor tissues had higher aflatoxin-adduct levels than did normal tissue from the same individual."
Instructions: your goal is to land accurately right on the platform. Control your ship with the arrow keys. You can slightly increase or decrese the descending of the ship with the up arrow key. Remember, slow down during landing! Good Luck...!!!
Customize your car in this awesome game and race on various exciting tracks to acheive one of top three positions.
Il bicarbonato di sodio è uno dei più potenti alcalinizzanti. Otto Heinrich Warburg, premio Nobel nel 1931 per la sua tesi La causa principale e la prevenzione del cancro, ha dichiarato: Le cellule tumorali vivono in un ambiente estremamente acido e privo di ossigeno. Le cellule sane vivono in un ambiente alcalino, ossigenato, consentendo il funzionamento normale, privare una cellula del 35% di ossigeno per 48 ore può probabilmente innescare un processo canceroso. Le sostanze acide respingono ossigeno, mentre le sostanze alcaline lo attraggono. Le cellule tumorali sono anaerobiche (non respirano ossigeno) e non possono sopravvivere in presenza di alti livelli di ossigeno. Invece la GLICEMIA sopravvive fino a quando l’ambiente è privo di ossigeno. I tessuti tumorali sono acidi, mentre i tessuti sani sono alcalini, quindi il cancro non sarebbe altro che un meccanismo di difesa che hanno alcune cellule del corpo per sopravvivere in un ambiente privo di ossigeno e alcalinità.
La dr. Elisabetta Izquierdo : “Io sono un medico e mi rifiuto di credere che radio e chemio terapia siano gli unici strumenti per debellare il cancro”.
Il bicarbonato di sodio, umile composto e molto a buon mercato, secondo recenti e sorprendenti ricerche farmaceutiche può curare il cancro. E non solo, allevia molto significativamente anche gli effetti secondari negativi della chemioterapia. La “soluzione” della medicina organizzata per il cancro si basa su tre procedure molto rischiose e altamente invasive la chirurgia, la chemioterapia e la radioterapia. La soluzione può essere nel kit del vostro bagno.
Dose Consigliata: 1/2 litro di acqua + succo di 3 limoni + 1 cucchiaino di bicarbonato di sodio. Prendere a stomaco vuoto al mattino, può essere suddivisa in due dosi durante il giorno , ma non tra i pasti. E ‘ meglio prenderla ogni giorno, anche quando la malattia è sparita, perché tutti i tumori possono tornare, ed è importante prevenire.
Nel suo libro, “Vincere la guerra al cancro“, il suo autore – il dottor Mark Sircus – affronta la questione del bicarbonato di sodio che aiuta a salvare innumerevoli vite ogni giorno. Il bicarbonato di sodio è noto come antico metodo per accelerare il ritorno a livelli normali di bicarbonato nel corpo. E’ inoltre economico, sicuro, e forse potrebbe essere la medicina più efficace a disposizione contro il cancro.
Il Bicarbonato di sodio dà al corpo una forma naturale di chemioterapia che uccide efficacemente le cellule tumorali senza gli effetti collaterali devastanti evitando anche i costi della chemioterapia convenzionale. Dal momento che nessuno si può arricchire e fare un sacco di soldi con qualcosa di così semplice, nessuno lo promuove e quindi manca il supporto per essere studiato e sperimentato. La comunità medica ha voltato le spalle Dr. Simoncini e ad altri colleghi, perché, da onesto specialista oncologo, ha rifiutato di utilizzare i metodi convenzionali per i suoi pazienti che decidono di farsi somministrare cure a base di bicarbonato di sodio, curando con impressionante successo nel 99 per cento dei casi il cancro al seno. Il cancro della vescica può essere curato in breve tempo, completamente e senza chirurgia, chemio o radioterapia, utilizzando solo un apparato di infiltrazione locale (simile ad un catetere) per infondere bicarbonato di sodio direttamente nella zona infetta del seno o della vescica, ma può anche essere consumato per via orale.
Il bicarbonato di sodio applicato ai tumori alla fine li fa scomparire rapidamente, che molti dei trattamenti chemioterapici attualmente includono bicarbonato di sodio, con la scusa che “aiuta” a proteggere i reni, il cuore e il sistema nervoso del paziente è un dato di fatto. Ed è stato già stabilito che la somministrazione di chemioterapia senza bicarbonato può uccidere il paziente. Così , quando sentiamo parlare sui “successi” della chemioterapia è proprio il bicarbonato di sodio che agisce, non solo per fermare metastasi ma anche per ridurre al minimo gli effetti collaterali dannosi della tossicità chemioterapica. Inoltre non esistono studi per separare gli effetti del bicarbonato di sodio dagli agenti chemioterapici tossici.
Instructions: your goal is to land accurately right on the platform. Control your ship with the arrow keys. You can slightly increase or decrese the descending of the ship with the up arrow key. Remember, slow down during landing! Good Luck...!!!
You're a get-away driver of an Arms Smuggling gang! Drive your jeep, pick up cargo and deliver it, while avoiding the cops.
The push to study cannabidiol, a non-psychoactive cannabis compound, as a treatment for children with severe epilepsy has finally led to clinical trials. Approved by the FDA, the studies will take place at five medical centers across the U.S., including the University of California, San Francisco (UCSF).
But contrary to earlier reports, researchers say only this month are studies on Epidiolex, a purified form of CBD, actually beginning.
The problem, as UCSF researcher Joseph Sullivan explained to KRCB Radio, is that federal law treats CBD the same way as all forms of marijuana, presenting significant legal barriers to medical research.
"There is no psychoactive or abuse potential of pure cannabidiol, yet it's treated as if it's any other type of marijuana with high THC levels."
Because of this, Sullivan and his colleagues at UCSF had to satisfy strict requirements, such as undergoing extensive background checks and purchasing a $3,000 safe, in order to start testing the drug.
And while medical marijuana advocates have shown support for the development, Dr. Sullivan seems to think researchers would be better off if they hadn't.
"Because of the current political climate – although it is changing – it tarnishes the effort to align it with medical marijuana, as opposed to just saying that this is cannabidiol. I think it's not positioning us well to get this medication out into the appropriate studies, so we understand what role it can play for us."
But considering how long studies on CBD have existed, it's uncertain whether progress would've been made if parents of epileptic children hadn't drawn attention to the issue.
Since 2012, major media sources such as CNN have reported success stories of parents of severely epileptic children, who found CBD-rich cannabis to be the only treatment that worked.
What's more, according to another member of the UCSF team, Dr. Catherine Jacobson, the company behind Epidiolex hadn't planned on testing the drug for epilepsy in the first place.
It wasn't until a parent contacted GW Pharmaceuticals seeking an alternative to CBD products available at local dispensaries, Dr. Jacobson told Leaf Science, that the company began to consider Epidiolex for treating seizures.
"They got interested in the pediatric epilepsy population because one parent in California got fed up with finding cannabidiol-enriched cannabis from dispensaries. From pot growers. She got fed up because it was impossible to find. It was a very inaccurate method for treating a child with severe seizures."
Before joining the team at UCSF, Dr. Jacobson worked at Stanford University, where she compiled data from parents who had tried CBD-rich marijuana as a treatment for their children.
Published last year, her study showed that most parents (83% of those surveyed) found CBD-rich marijuana effective at reducing seizure frequency, even when other drugs couldn't.
But despite the positive findings, Dr. Jacobson agrees with her colleague's message that more research is needed in order to determine the true promise of CBD.
While she believes CBD will work for some, Dr. Jacobson told KRCB that the "hype" around CBD-rich marijuana may not be accurate, and it's unlikely that cannabidiol can cure all forms of epilepsy.